{"id":"W4416217165","doi":"10.1016/s2468-1253(25)00296-1","title":"Safety and pharmacokinetics of SOR102, an oral bispecific inhibitor of TNF and interleukin-23 in healthy participants and patients with ulcerative colitis: a first-in-human, double-blind, randomised, placebo-controlled, phase 1 trial","year":2025,"lang":"en","type":"article","venue":"The Lancet. Gastroenterology & hepatology","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":5,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University","funders":"","keywords":"Pharmacokinetics; Tumor necrosis factor alpha; Clinical trial; Adverse effect; Randomized controlled trial","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00153178,0.001771596,0.002730789,0.0003029445,0.0003469115,0.001222055,0.0007547709,0.002654585,0.006261799],"category_scores_gemma":[0.002101544,0.0009432511,0.001626328,0.0003244612,0.001134983,0.001309543,0.0003224965,0.003417955,0.001408268],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005578944,"about_ca_system_score_gemma":0.000770212,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005711736,"about_ca_topic_score_gemma":0.0007048368,"domain_scores_codex":[0.9993535,0.000307071,0.00003674508,0.0001361526,0.00006415604,0.0001024505],"domain_scores_gemma":[0.9989254,0.0002968905,0.0002349843,0.00007595625,0.00007953576,0.0003872513],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9793394,0.004182682,0.0006501065,0.0003376601,0.0005803907,0.00004310743,0.00003745353,0.0001758393,0.003106828,0.00005035579,0.000560266,0.01093599],"study_design_scores_gemma":[0.8814884,0.1127356,0.003499146,0.00002682783,0.0004745277,0.00007579818,0.00003129348,0.0003610099,0.0005910545,0.0001425882,0.0005498552,0.00002379822],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9892099,0.004997572,0.0005426275,0.0005217059,0.000407067,0.001220061,0.001042612,0.0001235747,0.001934877],"genre_scores_gemma":[0.9914064,0.002166703,0.0005917347,0.0009073727,0.000359261,0.0009590702,0.001088345,0.00002924276,0.002491759],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006261799,"threshold_uncertainty_score":0.02094781,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03036555643774124,"score_gpt":0.3073341946590808,"score_spread":0.2769686382213395,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}