{"id":"W4416218920","doi":"10.2337/db25-0801","title":"Baseline Insulin Secretion Determines Response to Abatacept in Stage 1 Type 1 Diabetes","year":2025,"lang":"en","type":"article","venue":"Diabetes","topic":"Diabetes and associated disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity; University of Alberta","funders":"National Institutes of Health; Juvenile Diabetes Research Foundation International","keywords":"Abatacept; Type 1 diabetes; Hazard ratio; Stage (stratigraphy); Immune system; Diabetes mellitus; Insulin; Rheumatoid arthritis; Autoimmune disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004109395,0.0003682593,0.000899287,0.0002256028,0.0001102736,0.0006274643,0.0002383885,0.000505786,0.00111783],"category_scores_gemma":[0.004900283,0.0002893741,0.001598266,0.0003078188,0.0002343869,0.0003636768,0.0002908549,0.0007154833,0.0001658992],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002942162,"about_ca_system_score_gemma":0.000209999,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009156261,"about_ca_topic_score_gemma":0.0009845613,"domain_scores_codex":[0.9986167,0.0008667037,0.00007310063,0.0001698859,0.0001587288,0.0001149581],"domain_scores_gemma":[0.9963598,0.002509166,0.0005404844,0.0002959118,0.00009939471,0.0001952732],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.08680362,0.0008469593,0.8522727,0.0003303309,0.002730118,0.000251686,0.0001619329,0.006475838,0.01241087,0.00008772443,0.0005247009,0.03710349],"study_design_scores_gemma":[0.0007693524,0.01066745,0.9726849,0.00006024155,0.001605937,0.0003751201,0.00008581482,0.01020825,0.002841653,0.0003122271,0.0003581651,0.00003088826],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975763,0.001314797,0.0005054243,0.00003597663,0.00001574275,0.00001553337,0.0001583796,0.00001614633,0.0003617182],"genre_scores_gemma":[0.9995434,0.0001069044,0.0001242862,0.00003066723,0.000005163234,0.000005982527,0.000101687,0.000003129439,0.00007892647],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004109395,"threshold_uncertainty_score":0.02173281,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005235822438153216,"score_gpt":0.2435701272453672,"score_spread":0.238334304807214,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}