{"id":"W4416222300","doi":"10.1093/brain/awaf433","title":"GFAP and NfL as predictors of disease progression and relapse activity in fingolimod-treated multiple sclerosis","year":2025,"lang":"en","type":"article","venue":"Brain","topic":"Multiple Sclerosis Research Studies","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Population Health Research Institute","funders":"Novartis Pharma; EMD Serono; MedDay Pharmaceuticals; Innosuisse - Schweizerische Agentur für Innovationsförderung; Schweizerische Multiple Sklerose Gesellschaft; Deutschen Multiple Sklerose Gesellschaft; Shionogi; Westfälische Wilhelms-Universität Münster; National Research Foundation; Bayer HealthCare; Genentech; International Progressive MS Alliance; Vetenskapsrådet; Fresenius Medical Care North America; H. Lundbeck A/S; TG Therapeutics; Novocure; Multiple Sclerosis Society; European Committee for Treatment and Research in Multiple Sclerosis; Sanofi Genzyme; Universität Basel; F. Hoffmann-La Roche; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Alexion Pharmaceuticals; Teva Pharmaceutical Industries; Eli Lilly and Company; U.S. Department of Defense; GW Pharmaceuticals; Sanofi; Celgene; Servier; Gilead Sciences; Bayer; Pfizer; Biogen; GlaxoSmithKline; Bristol-Myers Squibb; Bundesministerium für Bildung und Forschung; Merck KGaA; National Science Foundation","keywords":"Multiple sclerosis; Fingolimod; Proportional hazards model; Longitudinal study; Glial fibrillary acidic protein; Cohort; Disease; Biomarker","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000851029,0.0002574327,0.0002777856,0.0007997425,0.0001918871,0.000449475,0.0002521237,0.0004378298,0.0006239652],"category_scores_gemma":[0.002283783,0.0001774838,0.0003434625,0.0005151994,0.0002117327,0.0002928612,0.0003007973,0.00044962,0.0001590077],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002224927,"about_ca_system_score_gemma":0.000254194,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002953295,"about_ca_topic_score_gemma":0.00263636,"domain_scores_codex":[0.9997389,0.00008950786,0.00002660041,0.00005872409,0.00005882011,0.0000274899],"domain_scores_gemma":[0.9987708,0.0003047875,0.0006087958,0.00005607449,0.00008663429,0.0001728997],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001254749,0.00004711361,0.9951397,0.00001128669,0.00008483249,0.00008381889,0.00004841115,0.0001198964,0.0004689685,0.00001062786,0.00004059584,0.002690078],"study_design_scores_gemma":[0.00001243051,0.0001924863,0.9985385,0.000004577113,0.00003488907,0.0002033258,0.00005250248,0.0007617488,0.0001032409,0.0000357297,0.00005802451,0.000002605115],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9993905,0.0003745893,0.00004098569,0.0000153118,0.000002153503,0.000002318733,0.0000862097,0.000003527835,0.00008437946],"genre_scores_gemma":[0.9995943,0.00008640855,0.00006311026,0.000005824709,0.000004684107,0.000003600517,0.0001477641,0.000001420367,0.00009293972],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002953295,"threshold_uncertainty_score":0.00587219,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03631842209821456,"score_gpt":0.3243997451715595,"score_spread":0.2880813230733449,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}