{"id":"W4416222336","doi":"10.1126/sciadv.adu0726","title":"CHCHD2 mutant mice link mitochondrial deficits to PD pathophysiology","year":2025,"lang":"en","type":"article","venue":"Science Advances","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Regina","funders":"National Center for Research Resources; National Institute of Neurological Disorders and Stroke; National Institute of General Medical Sciences; National Institute on Aging; National Institutes of Health; Canadian Institutes of Health Research; Parkinson Canada; University of California, San Francisco; Canada Foundation for Innovation; Michael J. Fox Foundation for Parkinson's Research","keywords":"Mitochondrion; Substantia nigra; Pathophysiology; Dopaminergic; Mutant; Mitochondrial DNA; Phenotype; Reactive oxygen species","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002023543,0.0009669053,0.000372094,0.0009045416,0.0003480056,0.0003155109,0.0003400297,0.0008201782,0.00292653],"category_scores_gemma":[0.0001898676,0.0003427047,0.0003414037,0.0002620506,0.000616628,0.0002922319,0.0004464424,0.001114657,0.0004060897],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004078396,"about_ca_system_score_gemma":0.0002567921,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000814381,"about_ca_topic_score_gemma":0.00174372,"domain_scores_codex":[0.9997916,0.000025894,0.00002639766,0.00007918442,0.00004613239,0.00003085181],"domain_scores_gemma":[0.9997328,0.00003540952,0.00009725754,0.00002043748,0.00002269588,0.00009150391],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000445206,0.0001705668,0.001306773,0.00008061509,0.00003209868,0.0008797108,0.00006049722,0.0001757499,0.9943469,0.0004155473,0.0002878289,0.001798414],"study_design_scores_gemma":[0.0004175729,0.001158711,0.05154019,0.00007412364,0.0001429399,0.007714489,0.0001952643,0.005096064,0.9253889,0.001203892,0.007031046,0.00003678128],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9864065,0.0009937314,0.007587603,0.0004473167,0.00007447177,0.0001009617,0.002144155,0.0002507384,0.001994567],"genre_scores_gemma":[0.9895504,0.0008505968,0.004695572,0.0002264025,0.00002904202,0.0001094704,0.00135165,0.00007640579,0.003110486],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00292653,"threshold_uncertainty_score":0.009790242,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00987461733103086,"score_gpt":0.3014803873416668,"score_spread":0.291605770010636,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}