{"id":"W4416224734","doi":"10.1038/s41467-025-64999-3","title":"Intrinsic dysfunction in muscle stem cells lacking dystrophin begins during secondary myogenesis","year":2025,"lang":"en","type":"article","venue":"Nature Communications","topic":"Muscle Physiology and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; Canadian Institutes of Health Research; Canadian HIV Trials Network, Canadian Institutes of Health Research; University of Ottawa; Stem Cell Network; Ontario Institute for Regenerative Medicine; Government of Canada; U.S. Department of Health and Human Services","keywords":"Dystrophin; Myogenesis; Duchenne muscular dystrophy; Stem cell; Myocyte; Muscular dystrophy; ITGA7; Progenitor cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000760195,0.0002980582,0.0002799458,0.0002881838,0.0001637044,0.0003203398,0.0001318363,0.0003099157,0.001337362],"category_scores_gemma":[0.00009280973,0.0001508033,0.0001915058,0.0001056412,0.0002638424,0.0001756313,0.0002647255,0.0004555749,0.0007101281],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002535757,"about_ca_system_score_gemma":0.000186709,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00060818,"about_ca_topic_score_gemma":0.0009688174,"domain_scores_codex":[0.9999007,0.000007828271,0.00001172926,0.00002943043,0.00003166519,0.00001868348],"domain_scores_gemma":[0.99985,0.00001722864,0.00004228163,0.00001393908,0.00001251413,0.00006397318],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002985182,0.000004455007,0.0003570318,0.00001600457,0.000001613792,0.0001061767,0.00001414663,0.00001991083,0.9988619,0.00006887339,0.00001856618,0.0005013684],"study_design_scores_gemma":[0.000006357661,0.000114097,0.02591914,0.00001333549,0.00001042779,0.001005476,0.00005537696,0.000372307,0.9694282,0.00006582357,0.003005791,0.000003631071],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9914836,0.001801841,0.003308122,0.00008070695,0.00002673019,0.00002083843,0.0009269968,0.0001850966,0.002166016],"genre_scores_gemma":[0.9922889,0.0009184691,0.001468481,0.00005245776,0.000006739845,0.00002847546,0.0008342329,0.00003925441,0.004362834],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001337362,"threshold_uncertainty_score":0.004473865,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007682280012683057,"score_gpt":0.2516820381444081,"score_spread":0.2439997581317251,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}