{"id":"W4416225015","doi":"10.1111/ggi.70251","title":"Patient With Mild Alzheimer's Disease Homozygous for <i>ApoE</i> ε4 Showing Improved Cognition, No Brain Volume Loss, and Complete Amyloid Clearance After Lecanemab Treatment","year":2025,"lang":"en","type":"article","venue":"Geriatrics and gerontology international/Geriatrics & gerontology international","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Apolipoprotein E; Magnetic resonance imaging; Dementia; Donepezil; Memory clinic; Pittsburgh compound B; Amyloid (mycology); Disease","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001570244,0.001015129,0.001305618,0.0009867206,0.001704926,0.0005065987,0.0004875968,0.00156364,0.001979765],"category_scores_gemma":[0.0009117719,0.0002648465,0.0007587232,0.0007421562,0.000561798,0.0006807985,0.0004520977,0.001303096,0.000681805],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005184438,"about_ca_system_score_gemma":0.0005245151,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003847691,"about_ca_topic_score_gemma":0.004703735,"domain_scores_codex":[0.9998202,0.0000159679,0.00002337076,0.00005206067,0.00003533378,0.00005317621],"domain_scores_gemma":[0.9997271,0.00004849463,0.00004433529,0.00002074615,0.00004406505,0.000115277],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"case_report","study_design_gemma":"case_report","study_design_scores_codex":[0.0003241209,0.0002170353,0.027485,0.0000634465,0.00002932362,0.9618312,0.0003053074,0.00008183344,0.003429626,0.0001718434,0.001194764,0.004866438],"study_design_scores_gemma":[0.0000495233,0.0006820845,0.03653268,0.00002908508,0.00007853586,0.9589528,0.0001562423,0.0003266578,0.001236662,0.0002445411,0.001678515,0.00003257421],"study_design_candidate":"case_report","study_design_consensus":"case_report","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9771031,0.002623911,0.001169264,0.002529237,0.0002809767,0.0001854544,0.0003297466,0.0001455646,0.01563272],"genre_scores_gemma":[0.9943544,0.000924673,0.0005346072,0.001339981,0.0003106203,0.0000164823,0.0001251845,0.00001530758,0.002378888],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003847691,"threshold_uncertainty_score":0.007650614,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01916372043700296,"score_gpt":0.2984203684697564,"score_spread":0.2792566480327534,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}