{"id":"W4416226414","doi":"10.1101/2025.11.10.686860","title":"eIF2B Selectively Anchors and Activates Mutant KRAS","year":2025,"lang":"","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; Jewish General Hospital; University Health Network; McGill University","funders":"Canadian Institutes of Health Research","keywords":"Guanine nucleotide exchange factor; Mutant; Allosteric regulation; KRAS; Translation (biology); Regulator; Glycosphingolipid; Translational regulation; eIF2; Eukaryotic translation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001047866,0.0004091368,0.0001958059,0.0002452745,0.0001392777,0.0001895655,0.0001388959,0.000233105,0.004755545],"category_scores_gemma":[0.0000984131,0.0001181823,0.000213498,0.0001664043,0.0001167847,0.0001465973,0.0001943738,0.000516978,0.0009236275],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003134508,"about_ca_system_score_gemma":0.0001603928,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003325358,"about_ca_topic_score_gemma":0.0004178167,"domain_scores_codex":[0.9998815,0.000009714198,0.00000501627,0.00002717331,0.00003997209,0.00003659945],"domain_scores_gemma":[0.9999535,0.000005867901,0.0000135867,0.000003834627,0.000005874154,0.00001731425],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001817062,0.00002525371,0.0002310439,0.000117739,0.000007862713,0.00006166357,0.00001006317,0.0001465473,0.9956883,0.0002599195,0.0007500432,0.002519949],"study_design_scores_gemma":[0.00002570209,0.0001364765,0.002786308,0.00001374506,0.00000976297,0.0001197902,0.00002491006,0.00196415,0.9872561,0.0001430229,0.00751405,0.000006045812],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9776551,0.003409332,0.00645476,0.0007072801,0.000366134,0.00005104684,0.002488015,0.0005831125,0.008285262],"genre_scores_gemma":[0.9917091,0.0008907812,0.001630491,0.0001210465,0.00002474444,0.00002604417,0.001314941,0.00004154558,0.004241292],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004755545,"threshold_uncertainty_score":0.0159089,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008712499112222603,"score_gpt":0.2288077110389694,"score_spread":0.2200952119267468,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}