{"id":"W4416227257","doi":"10.1002/em.70067","title":"Evaluation of Type 1 Error Rates in Duplex Sequencing for Mutagenicity Testing Using Vehicle Control Data and Simulation Analyses","year":2025,"lang":"en","type":"article","venue":"Environmental and Molecular Mutagenesis","topic":"Carcinogens and Genotoxicity Assessment","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Health Canada","funders":"Health Canada; Canada Research Chairs; Burroughs Wellcome Fund","keywords":"Mutagenesis; Mutation; Duplex (building); Focus (optics); Sequence (biology); Type I and type II errors","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.07749107,0.001513723,0.001493929,0.001914042,0.0005854872,0.001253102,0.001624251,0.001577832,0.001944367],"category_scores_gemma":[0.128299,0.0006792289,0.002323786,0.001113344,0.00143349,0.001156603,0.001328921,0.002140818,0.0002192398],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001345836,"about_ca_system_score_gemma":0.00202193,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002787579,"about_ca_topic_score_gemma":0.002468981,"domain_scores_codex":[0.9674758,0.02356018,0.002348178,0.00314411,0.00288878,0.0005830898],"domain_scores_gemma":[0.7165378,0.250194,0.01257326,0.01114065,0.008815615,0.0007386833],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.003638396,0.001078158,0.09587455,0.001747242,0.002500228,0.0006494024,0.001208799,0.7590616,0.02843333,0.02639389,0.002123515,0.07729096],"study_design_scores_gemma":[0.000132411,0.001224752,0.009640304,0.0001523213,0.0002922795,0.0001981693,0.0001631205,0.9579543,0.02029291,0.00785812,0.001981735,0.0001095866],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.2809453,0.0007781388,0.7127956,0.000225128,0.0001647527,0.001714731,0.000956259,0.001096593,0.001323548],"genre_scores_gemma":[0.6735753,0.0002291826,0.3211463,0.0002126657,0.00002357988,0.002733016,0.001243276,0.0002226266,0.0006140536],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.07749107,"threshold_uncertainty_score":0.4098169,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1170862725035173,"score_gpt":0.3905617029916522,"score_spread":0.2734754304881349,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}