{"id":"W4416231112","doi":"10.3390/bioengineering12111246","title":"Preclinical Mechanistic Evaluation of Hyaluronan/Niacinamide (Vitamin B3) Hydrogels: Toward an Enhanced Viscosupplement System with Ancillary Anti-Arthritic Attributes","year":2025,"lang":"en","type":"article","venue":"Bioengineering","topic":"Osteoarthritis Treatment and Mechanisms","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Hôpital du Sacré-Cœur de Montréal","funders":"","keywords":"Self-healing hydrogels; Hyaluronic acid; Chondrocyte; Viscosupplementation; Cytotoxicity; Niacinamide; In vivo; Osteoarthritis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000293642,0.0003935324,0.0001684067,0.0001487475,0.0001054519,0.0002224927,0.0002340318,0.0003129602,0.0008618951],"category_scores_gemma":[0.0001155743,0.0001082939,0.0002444812,0.0001069551,0.0001571396,0.0002532095,0.0001103112,0.0004990522,0.0001480879],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001879983,"about_ca_system_score_gemma":0.0001974729,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004543597,"about_ca_topic_score_gemma":0.0007381063,"domain_scores_codex":[0.9999177,0.0000133996,0.000007802362,0.00001344704,0.00002347826,0.00002418758],"domain_scores_gemma":[0.9998913,0.00001789058,0.00003758675,0.000005962903,0.00002037078,0.00002689236],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001582221,0.0001336202,0.00004491065,0.00007261832,0.000004174199,0.00002375614,0.00000988979,0.0001369514,0.9985602,0.00003551157,0.00001858069,0.0008016183],"study_design_scores_gemma":[0.00002334319,0.002952056,0.0005875048,0.000008241112,0.00002213117,0.000055869,0.00001934766,0.0005484706,0.9948461,0.0000200202,0.0009127143,0.000004098305],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939323,0.001726079,0.003035696,0.00006960231,0.00002623826,0.0001096791,0.0003070362,0.00003363325,0.0007597111],"genre_scores_gemma":[0.9927946,0.001627079,0.003869507,0.00004536341,0.000008605084,0.0001270769,0.0002623727,0.000007468787,0.001257962],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008618951,"threshold_uncertainty_score":0.002883315,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03170623534320077,"score_gpt":0.3004850301384214,"score_spread":0.2687787947952207,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}