{"id":"W4416231759","doi":"10.20944/preprints202511.1001.v1","title":"Expanding Horizons: Host Range Evolution and Treatment Strategies for Highly Pathogenic H5N1 Avian Influenza","year":2025,"lang":"","type":"preprint","venue":"Preprints.org","topic":"Influenza Virus Research Studies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Influenza A virus subtype H5N1; Highly pathogenic; Pandemic; Influenza A virus; Transmission (telecommunications); Public health; Host (biology); Orthomyxoviridae","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001920415,0.000350781,0.000428005,0.0004404251,0.0004258011,0.001931147,0.0007214102,0.001459093,0.008607475],"category_scores_gemma":[0.002773141,0.0001374673,0.0004704099,0.0002232769,0.0004796716,0.001731746,0.0008270284,0.001551343,0.002267807],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007052275,"about_ca_system_score_gemma":0.001101158,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001004565,"about_ca_topic_score_gemma":0.00182798,"domain_scores_codex":[0.9995626,0.0001931873,0.00001583744,0.00006130117,0.00009802403,0.00006896944],"domain_scores_gemma":[0.9993417,0.0002510337,0.00007660522,0.00005314001,0.0001153571,0.0001622011],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007097927,0.000516328,0.008321533,0.001164042,0.0001466344,0.0003578461,0.000325067,0.002818714,0.01601337,0.01473981,0.07580581,0.879081],"study_design_scores_gemma":[0.0004460379,0.004101514,0.03347502,0.003591222,0.0005198341,0.002551821,0.004538336,0.02431019,0.02178174,0.1290744,0.7754083,0.0002015476],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.09163102,0.5403249,0.05359169,0.2459278,0.007283614,0.0003067769,0.001119524,0.0009454056,0.05886913],"genre_scores_gemma":[0.6281138,0.2473719,0.06105486,0.03120444,0.008314602,0.000327988,0.001425951,0.000235235,0.02195129],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.008607475,"threshold_uncertainty_score":0.02879488,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2172343397896541,"score_gpt":0.433576725091263,"score_spread":0.216342385301609,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}