{"id":"W4416239125","doi":"10.1016/j.vaccine.2025.127975","title":"Intranasal CD40-targeted recombinant MERS-CoV S1 protein is superior to intramuscular immunization in eliciting systemic and mucosal immune responses in mice","year":2025,"lang":"en","type":"article","venue":"Vaccine","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Canada","funders":"King Abdulaziz University; Deanship of Scientific Research, King Khalid University","keywords":"Immunogenicity; Nasal administration; Adjuvant; Immune system; Immunization; Antibody; Humoral immunity; Vaccination","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003508707,0.0008045791,0.0004370741,0.0004998859,0.0001463245,0.0003119751,0.0002607472,0.0007436047,0.000651742],"category_scores_gemma":[0.000182983,0.0002880374,0.0004690505,0.0001470729,0.0003719458,0.0004469438,0.0001859482,0.001275295,0.0002640704],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003142791,"about_ca_system_score_gemma":0.0003181081,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005937175,"about_ca_topic_score_gemma":0.0007109325,"domain_scores_codex":[0.9996186,0.00006173218,0.00003590567,0.00009124487,0.00008448167,0.0001080303],"domain_scores_gemma":[0.9998145,0.00001928011,0.00006510086,0.00001897346,0.00002400637,0.00005824094],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003785667,0.0001977092,0.0001078169,0.00006082,0.000007199278,0.00002280922,0.00002298169,0.00008560087,0.9978453,0.00004323404,0.0000354635,0.001192369],"study_design_scores_gemma":[0.000116899,0.005814199,0.002650751,0.00001824134,0.00005534245,0.0001985484,0.00004092676,0.001285296,0.9881548,0.0000624482,0.001592499,0.00001008407],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952832,0.001410223,0.001745238,0.0001612422,0.0000636335,0.00005792316,0.0002142648,0.0001151578,0.0009492344],"genre_scores_gemma":[0.9929106,0.001241612,0.002520252,0.0001296445,0.00003662271,0.00007001004,0.000345868,0.00002646628,0.002719115],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008045791,"threshold_uncertainty_score":0.002280295,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01419342182500611,"score_gpt":0.3086075175347004,"score_spread":0.2944140957096943,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}