{"id":"W4416239499","doi":"10.1158/1078-0432.ccr-25-3040","title":"Real-World Outcomes of Elacestrant in ER+, HER2−, <i>ESR1</i> -Mutant Metastatic Breast Cancer","year":2025,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Innovative Research Group (Canada)","funders":"Menarini Group","keywords":"Metastatic breast cancer; Breast cancer; PI3K/AKT/mTOR pathway; Cancer; MEDLINE","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003192789,0.000338037,0.000614161,0.0004052095,0.000267195,0.0008789808,0.0004776409,0.0004911071,0.002358839],"category_scores_gemma":[0.009625803,0.0001698878,0.00117192,0.0008885662,0.0003224347,0.0008127898,0.0005887474,0.0008913216,0.0003329564],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001171407,"about_ca_system_score_gemma":0.0004760743,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002271497,"about_ca_topic_score_gemma":0.002675841,"domain_scores_codex":[0.99787,0.001061479,0.0002311843,0.0004719968,0.000207415,0.0001579414],"domain_scores_gemma":[0.9907377,0.002931342,0.004799088,0.0004680279,0.0004004549,0.0006633826],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.03955327,0.000718225,0.929078,0.0005092269,0.002494229,0.0002340071,0.0001774733,0.0050096,0.0004719061,0.0004168164,0.004026283,0.01731099],"study_design_scores_gemma":[0.002490446,0.005375803,0.9787204,0.0001821422,0.001513985,0.0006073672,0.0002953067,0.005337085,0.0006195001,0.0007207472,0.004070318,0.00006681387],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9891084,0.00137338,0.0001921253,0.0002910141,0.00002512966,0.00003961887,0.008146323,0.000008215113,0.0008158105],"genre_scores_gemma":[0.9915943,0.0002676459,0.0001278241,0.00008824956,0.00002961207,0.00005197095,0.007681703,0.000003295449,0.0001555008],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003192789,"threshold_uncertainty_score":0.01688522,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.168871528857393,"score_gpt":0.562525891090164,"score_spread":0.3936543622327711,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}