{"id":"W4416239499","doi":"10.1158/1078-0432.ccr-25-3040","title":"Real-World Outcomes of Elacestrant in ER+, HER2−, <i>ESR1</i> -Mutant Metastatic Breast Cancer","year":2025,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Innovative Research Group (Canada)","funders":"Menarini Group","keywords":"Metastatic breast cancer; Breast cancer; PI3K/AKT/mTOR pathway; Cancer; MEDLINE","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.003029746,0.000297262,0.001439371,0.0007001195,0.00009163261,0.00002276985,0.0004749909,0.0001397432,0.001085225],"category_scores_gemma":[0.0004454433,0.0002319202,0.0003101821,0.002423469,0.001112227,0.0001426854,0.0002188098,0.001591601,0.00002166868],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008388339,"about_ca_system_score_gemma":0.002695543,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.01683873,"about_ca_topic_score_gemma":0.01847217,"domain_scores_codex":[0.9950363,0.0006012906,0.001528296,0.0007960628,0.001105845,0.0009321736],"domain_scores_gemma":[0.9959619,0.001924227,0.0002060138,0.0008643472,0.0007319622,0.0003115413],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.004630374,0.0009752816,0.8388047,0.0007108923,0.0006247548,0.0001305507,0.000174634,0.0001191079,0.002135186,0.001271244,0.0008254746,0.1495979],"study_design_scores_gemma":[0.006714132,0.0002437607,0.9758298,0.001644908,0.0001490315,0.000008527478,0.0003621861,0.0001330354,0.002399997,0.002247077,0.01004077,0.0002267187],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9592206,0.004137784,0.00006358597,0.03018938,0.0007248095,0.001505904,0.0003162346,0.00007679989,0.003764915],"genre_scores_gemma":[0.9852497,0.006186265,0.0005308728,0.001129465,0.0002153404,0.000586184,0.000008077089,0.00005835777,0.006035729],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1493711,"threshold_uncertainty_score":0.9998279,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.168871528857393,"score_gpt":0.562525891090164,"score_spread":0.3936543622327711,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}