{"id":"W4416242442","doi":"10.1245/s10434-025-18734-3","title":"ASO Author Reflections: Risk Management Strategies for Older Women With Germline Pathogenic Variants in BRCA1/2 and PALB2","year":2025,"lang":"en","type":"article","venue":"Annals of Surgical Oncology","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; Jewish General Hospital","funders":"","keywords":"Surgical oncology; Germline; PALB2; MEDLINE; Risk management; Risk assessment","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00358785,0.0007230234,0.0009201729,0.001021803,0.002622877,0.003270905,0.00160509,0.02541091,0.00970999],"category_scores_gemma":[0.0272273,0.0005646936,0.001116673,0.0006613642,0.00130875,0.002377986,0.001701787,0.02250879,0.006281131],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002031742,"about_ca_system_score_gemma":0.005560594,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004598689,"about_ca_topic_score_gemma":0.01250555,"domain_scores_codex":[0.9977444,0.0005354016,0.000309396,0.000286222,0.0007857189,0.0003389142],"domain_scores_gemma":[0.979345,0.007347578,0.0009737518,0.0005287126,0.007151257,0.004653645],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00003387905,0.00004119183,0.001200451,0.00005037109,0.00000990939,0.0004690512,0.00008862619,0.00004670339,0.00008663247,0.0004109499,0.9851279,0.01243426],"study_design_scores_gemma":[0.0001151861,0.00009485461,0.002483801,0.0006241022,0.00006975335,0.001770647,0.000756791,0.000245411,0.0002202067,0.002644922,0.9909086,0.00006561996],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.0004967992,0.002798049,0.0001844673,0.8680503,0.1246898,0.00001449232,0.00006491532,0.00003287195,0.00366816],"genre_scores_gemma":[0.006006672,0.006077694,0.0007511971,0.7719494,0.1992654,0.0000590558,0.00006485164,0.00003615598,0.01578954],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.02541091,"threshold_uncertainty_score":0.03248316,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03242105119838904,"score_gpt":0.3812430571392676,"score_spread":0.3488220059408786,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}