{"id":"W4416245849","doi":"10.1016/j.lanhl.2025.100767","title":"Cognitive changes in older adults receiving pharmacotherapy for treatment-resistant depression: a secondary analysis of the OPTIMUM randomised controlled trial","year":2025,"lang":"en","type":"article","venue":"The Lancet Healthy Longevity","topic":"Treatment of Major Depression","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre for Addiction and Mental Health","funders":"Taylor Family Institute for Innovative Psychiatric Research, Washington University School of Medicine in St. Louis; National Institute of Mental Health; McDonnell Center for Systems Neuroscience; National Institutes of Health; University of Toronto; University of Oxford; Patient-Centered Outcomes Research Institute; Providence Health Care; Canadian Institutes of Health Research; Centre for Addiction and Mental Health Foundation; University of Maryland School of Public Health; Fondation Brain Canada; University of Pittsburgh; Johns Hopkins University; Usona Institute; Michael Smith Health Research BC; Biogen; U.S. Department of Defense","keywords":"Randomized controlled trial; Pharmacotherapy; Cognition; Mental health; Cognitive therapy; Cognitive training; Clinical trial","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01185892,0.001919659,0.006872989,0.001125764,0.0005191737,0.001420824,0.000949265,0.002118127,0.006601388],"category_scores_gemma":[0.01998923,0.0006577251,0.007637582,0.001181796,0.0009071866,0.001337963,0.00101165,0.002002631,0.0004109575],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001047439,"about_ca_system_score_gemma":0.001626233,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001293332,"about_ca_topic_score_gemma":0.002344031,"domain_scores_codex":[0.9881682,0.008603035,0.001258426,0.0008680107,0.0006306673,0.000471599],"domain_scores_gemma":[0.9884374,0.005504179,0.003387481,0.001031162,0.001013702,0.0006260826],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.964788,0.0007030809,0.002059574,0.007441686,0.01622477,0.00005792678,0.00006178052,0.0002447268,0.0004076642,0.0001964132,0.0007973955,0.007016816],"study_design_scores_gemma":[0.9546923,0.02021663,0.006728899,0.0005459014,0.01557794,0.00005346672,0.00003692021,0.0004570045,0.0001792091,0.0004779113,0.001004424,0.00002933875],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9108102,0.03829744,0.003512629,0.001434693,0.001645307,0.02986259,0.008929438,0.0002158001,0.005292094],"genre_scores_gemma":[0.9596103,0.005228098,0.00365057,0.001204883,0.000866754,0.02518092,0.002743661,0.00003179313,0.001482991],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01185892,"threshold_uncertainty_score":0.06271672,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03096974875605208,"score_gpt":0.3657838913873939,"score_spread":0.3348141426313418,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}