{"id":"W4416247285","doi":"10.1007/s13555-025-01592-y","title":"Matching-Adjusted Indirect Comparison of the Efficacy of Delgocitinib Cream and Dupilumab in the Treatment of Moderate to Severe Atopic Hand Eczema","year":2025,"lang":"en","type":"article","venue":"Dermatology and Therapy","topic":"Dermatology and Skin Diseases","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"LEO Pharma","keywords":"Dupilumab; Hand eczema; Atopic dermatitis; MEDLINE; Immunopathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00936395,0.001240701,0.002562134,0.0006292684,0.0002584131,0.0008303449,0.0009435428,0.0008524899,0.005037781],"category_scores_gemma":[0.01353508,0.0004334943,0.004561292,0.0004780128,0.0005402381,0.0005472539,0.0008288975,0.001134477,0.0002789831],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008240616,"about_ca_system_score_gemma":0.0007090897,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001194398,"about_ca_topic_score_gemma":0.00113374,"domain_scores_codex":[0.9909072,0.0069557,0.0005387285,0.0006407629,0.000668889,0.0002886693],"domain_scores_gemma":[0.9932016,0.004311993,0.001236466,0.0006449933,0.0003519056,0.0002531082],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.8929014,0.001342255,0.01763499,0.002420213,0.04313454,0.00006358151,0.0001375969,0.003601652,0.002312786,0.0007111938,0.0005394915,0.03520026],"study_design_scores_gemma":[0.3867585,0.2960809,0.1513446,0.0006421456,0.1234888,0.0004819747,0.0002557896,0.02050463,0.00986815,0.003755184,0.006606105,0.0002132139],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9854123,0.005857631,0.003169381,0.0001440798,0.0002898039,0.001458327,0.001314898,0.00004922061,0.002304274],"genre_scores_gemma":[0.9966964,0.0003916435,0.001307382,0.0000932266,0.00004685306,0.0006254442,0.000461054,0.000004969694,0.0003730892],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00936395,"threshold_uncertainty_score":0.04952186,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02464801680183747,"score_gpt":0.3149663567128831,"score_spread":0.2903183399110456,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}