{"id":"W4416247483","doi":"10.1021/acsabm.5c01744","title":"Controlling Enzymatic Degradation of Carboxyl-Modified Chitosan and Hyaluronic Acid Biopolymers Using Dynamic Covalent Cross-Linking","year":2025,"lang":"en","type":"article","venue":"ACS Applied Bio Materials","topic":"Hydrogels: synthesis, properties, applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"Dalhousie University; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs","keywords":"Covalent bond; Hyaluronic acid; Degradation (telecommunications); Hyaluronidase; Viscoelasticity; Chitosan; Aqueous solution","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000308553,0.0002350218,0.0003678316,0.0001049143,0.0001698148,0.00009218821,0.0002272013,0.000216316,0.000006972137],"category_scores_gemma":[0.00004160876,0.0002234837,0.00004492229,0.0001279682,0.0002213897,0.000006763493,0.000158784,0.00005046126,0.00000186436],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003091499,"about_ca_system_score_gemma":0.0001136221,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008380657,"about_ca_topic_score_gemma":0.0000105431,"domain_scores_codex":[0.9985132,0.00006153105,0.0005783828,0.0004426691,0.0001259482,0.0002782841],"domain_scores_gemma":[0.9991595,0.00001956335,0.0002847448,0.0004508515,0.00004087683,0.00004446945],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001191089,0.00003517846,0.0001406346,0.0001680489,0.00011477,1.749643e-7,0.00003139225,0.0001221869,0.9972489,0.0006313828,0.00000108328,0.001387156],"study_design_scores_gemma":[0.0006983148,0.00003067664,0.0004166301,0.00006435453,0.0001036062,0.000002865651,0.00005508312,0.0003465864,0.9978448,0.0001757148,0.00005613237,0.0002052776],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947568,0.001229563,0.002914049,0.00004192609,0.0001329808,0.0006327035,0.00007000253,0.00002495042,0.0001970377],"genre_scores_gemma":[0.9984643,0.0001951718,0.0008414944,0.00009195958,0.00004989978,0.0001181053,0.0001743302,0.00003201623,0.00003267438],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003707561,"threshold_uncertainty_score":0.91134,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01386524193818476,"score_gpt":0.266335429879087,"score_spread":0.2524701879409022,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}