{"id":"W4416257035","doi":"10.1212/wnl.0000000000214320","title":"Consensus-Based Expert Recommendations for Diagnosis and Clinical Management of Vanishing White Matter","year":2025,"lang":"en","type":"article","venue":"Neurology","topic":"RNA regulation and disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Children's Hospital; Montreal Neurological Institute and Hospital; McGill University; McGill University Health Centre","funders":"","keywords":"Clinical trial; Leukodystrophy; Disease; Stressor; Delphi method; MEDLINE; Disease management; Genetic testing","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.1725119,0.002281938,0.002950195,0.009869589,0.003700095,0.006101358,0.007871268,0.01265789,0.009185653],"category_scores_gemma":[0.3242787,0.001705227,0.00758457,0.004163121,0.003134599,0.007236076,0.01096939,0.01085398,0.004433889],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.009361018,"about_ca_system_score_gemma":0.03773027,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00574953,"about_ca_topic_score_gemma":0.006103596,"domain_scores_codex":[0.7833766,0.1459085,0.04236689,0.004414842,0.01965492,0.004278237],"domain_scores_gemma":[0.6847133,0.1741428,0.01836751,0.007474401,0.1041344,0.01116768],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0005271859,0.0005702275,0.00452149,0.05545274,0.001124429,0.002231484,0.01992782,0.003875905,0.002653118,0.02458079,0.2998997,0.5846352],"study_design_scores_gemma":[0.001016001,0.0004722106,0.004904038,0.2018242,0.001676255,0.001885563,0.01722111,0.005129022,0.001465711,0.0774226,0.6863652,0.0006180804],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"other","genre_scores_codex":[0.01685744,0.1075562,0.1564776,0.593864,0.01789851,0.03936897,0.003731219,0.001129547,0.06311656],"genre_scores_gemma":[0.1434891,0.06428588,0.6675966,0.07468569,0.00349993,0.03146388,0.005487392,0.0003619585,0.009129493],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.1725119,"threshold_uncertainty_score":0.9123411,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02604192684562738,"score_gpt":0.3436920747386951,"score_spread":0.3176501478930677,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}