{"id":"W4416263763","doi":"10.1002/dta.3969","title":"Identification of Metabolites for the Novel 5α‐Reductase Inhibitor Epristeride In Vitro and Its Potential Impact on Doping Testing","year":2025,"lang":"en","type":"article","venue":"Drug Testing and Analysis","topic":"Urinary Bladder and Prostate Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Ministry of Science and Technology of the People's Republic of China; Shanghai University of Sport; World Anti-Doping Agency","keywords":"Metabolite; Glucuronidation; Metabolic pathway; CYP3A4; Docking (animal); Microsome; In vitro","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000834782,0.0001020397,0.0002886451,0.000429853,0.0001490229,0.000053668,0.00005002313,0.00002468663,0.000001509768],"category_scores_gemma":[0.002071372,0.00006797564,0.00008756868,0.001242059,0.00004702595,0.00005427351,0.00004669757,0.0001182584,1.702266e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001837203,"about_ca_system_score_gemma":0.00006367303,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000267623,"about_ca_topic_score_gemma":0.000002244103,"domain_scores_codex":[0.9990945,0.00004137765,0.0003206535,0.0002369531,0.000133944,0.0001725723],"domain_scores_gemma":[0.9981378,0.001377357,0.0001031423,0.0001481853,0.0001844076,0.00004915103],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0002520205,0.0001169449,0.04832828,0.0002889577,0.0004845139,0.000003864742,0.0002746148,0.0007336503,0.9298632,0.00001351898,0.00001503586,0.01962542],"study_design_scores_gemma":[0.001299865,0.0001057809,0.2845915,0.0002706508,0.002137744,0.00001487364,0.0006489253,0.5008257,0.2097634,0.0002081143,0.00000651653,0.0001269507],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996724,0.001625509,0.0006472586,0.0005932875,0.00002259119,0.0002663774,0.00007138982,0.00001415567,0.00003543143],"genre_scores_gemma":[0.9985431,0.00004145715,0.001153477,0.00002776572,0.00004089089,0.00002190167,0.00002749295,0.000006351008,0.0001375888],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7200997,"threshold_uncertainty_score":0.2771966,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03655948801425164,"score_gpt":0.3472736949465534,"score_spread":0.3107142069323018,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}