{"id":"W4416275548","doi":"10.1016/j.ymthe.2025.11.020","title":"Mesenchymal stromal cells engineered with ACE2 for treatment of receptor-mediated viral lung injury","year":2025,"lang":"en","type":"article","venue":"Molecular Therapy","topic":"Mesenchymal stem cell research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Canada Research Chairs; SickKids Foundation; University of Toronto; Sunnybrook Health Science Centre; Hospital for Sick Children; St. Michael's Hospital","funders":"Canadian Institutes of Health Research","keywords":"Mesenchymal stem cell; ARDS; Reprogramming; Stromal cell; Viral replication; Inflammation; Lung","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001683058,0.0002622068,0.000221821,0.0001967647,0.0001409691,0.0003483395,0.0001179527,0.0002527878,0.001086134],"category_scores_gemma":[0.0000660221,0.00008276965,0.0002181784,0.0001357629,0.0001723782,0.0001710496,0.0001282774,0.0005025311,0.0002506093],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001507533,"about_ca_system_score_gemma":0.0001794349,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004252876,"about_ca_topic_score_gemma":0.0008175432,"domain_scores_codex":[0.9998965,0.00001344237,0.000005849324,0.00001275902,0.00004092764,0.000030591],"domain_scores_gemma":[0.9999604,0.000007504595,0.000009100249,0.000003803956,0.000005288599,0.00001391305],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002124238,0.00008343194,0.00009820003,0.00003097575,0.000008151475,0.0000951682,0.00001885615,0.0001657275,0.9970881,0.0001936828,0.00007498023,0.001930259],"study_design_scores_gemma":[0.00004471499,0.0003892033,0.0009055409,0.00000317879,0.00002646819,0.0001887341,0.00002447132,0.001249368,0.9938648,0.00004045215,0.00325915,0.000004004312],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9911529,0.001394556,0.00427526,0.0001216732,0.0001521892,0.00005687218,0.0003006012,0.00007455453,0.002471378],"genre_scores_gemma":[0.9943482,0.0007497824,0.002127781,0.00006512181,0.00002562235,0.00003051872,0.0002100162,0.00001336551,0.002429609],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001086134,"threshold_uncertainty_score":0.003633499,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01169801036978807,"score_gpt":0.3028484682114213,"score_spread":0.2911504578416332,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}