{"id":"W4416275715","doi":"10.1016/j.expneurol.2025.115557","title":"Domain-specific mutations in Na+/K+-ATPase α subunit differentially regulate sleep and circadian rhythms in Drosophila","year":2025,"lang":"en","type":"article","venue":"Experimental Neurology","topic":"Ion Transport and Channel Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Fuzhou University; Natural Science Foundation of Fujian Province; National Natural Science Foundation of China; Canadian Anesthesiologists' Society","keywords":"Circadian rhythm; Intracellular; Transmembrane domain; Mutation; Protein subunit; Circadian clock; Mutant; Transmembrane protein","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009473369,0.0003495166,0.0001603237,0.0003853826,0.0002177555,0.0002440128,0.000319711,0.0003019883,0.001304605],"category_scores_gemma":[0.0001641866,0.0002247682,0.0002363036,0.0001492794,0.0005382559,0.0002253774,0.0002810503,0.0005895433,0.0002607489],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005023679,"about_ca_system_score_gemma":0.0001952742,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001774997,"about_ca_topic_score_gemma":0.0054468,"domain_scores_codex":[0.9998991,0.00001372093,0.00001803465,0.00002981578,0.00002133652,0.00001792029],"domain_scores_gemma":[0.9997575,0.00005078588,0.0001003435,0.00001887116,0.00001526607,0.00005721348],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001031998,0.00001013244,0.0002700994,0.00001423677,0.000005643562,0.0001045938,0.00001987138,0.00008194808,0.9985021,0.0001990641,0.00003019521,0.0006589516],"study_design_scores_gemma":[0.0001035087,0.0001572986,0.03759871,0.00002706697,0.00006545978,0.0009607627,0.0002211494,0.002493059,0.9550174,0.0002773704,0.003058027,0.0000202385],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966105,0.0004324097,0.001395616,0.00006962512,0.00002888922,0.00001643945,0.0002949481,0.00004498745,0.001106607],"genre_scores_gemma":[0.9955487,0.0003678848,0.001087675,0.00009105684,0.000005578227,0.00001958395,0.0002255026,0.00005734324,0.002596699],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001774997,"threshold_uncertainty_score":0.004364312,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006981625456485206,"score_gpt":0.232477214381087,"score_spread":0.2254955889246018,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}