{"id":"W4416291649","doi":"10.1038/s42003-025-08955-3","title":"Cryo-EM analysis of the Staphylococcus aureus phenol-soluble modulin exporter PmtCD apo form in detergent micelles, nanodiscs and peptidiscs","year":2025,"lang":"en","type":"article","venue":"Communications Biology","topic":"Antimicrobial Resistance in Staphylococcus","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia Hospital; University of British Columbia","funders":"Biological and Environmental Research; National Institute of General Medical Sciences; Howard Hughes Medical Institute; National Institute of Allergy and Infectious Diseases; British Columbia Knowledge Development Fund; Canadian Institutes of Health Research; Mitacs; U.S. Department of Health and Human Services; National Institutes of Health; Canada Research Chairs; Oregon Health and Science University; U.S. Department of Energy","keywords":"Transmembrane protein; Secretion; Staphylococcus aureus; Transmembrane domain; Membrane protein; ATP-binding cassette transporter; Membrane; Transporter","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001346611,0.0002792951,0.0001384738,0.000123974,0.0004224668,0.000274606,0.0003208625,0.000386942,0.001746016],"category_scores_gemma":[0.0001892978,0.0001543272,0.000187682,0.000171094,0.0002948031,0.0003458271,0.0002233693,0.0009519078,0.0003522688],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005433974,"about_ca_system_score_gemma":0.0001723668,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002381438,"about_ca_topic_score_gemma":0.002030382,"domain_scores_codex":[0.999958,0.0000043651,0.000002831327,0.000008782848,0.00001536416,0.00001052831],"domain_scores_gemma":[0.9999044,0.00002752583,0.00001722247,0.000008187746,0.00002552905,0.00001723926],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00042133,0.00009861158,0.002505109,0.0002515625,0.0000654272,0.000986216,0.000349103,0.002227514,0.9883767,0.001296583,0.000947819,0.002474031],"study_design_scores_gemma":[0.00007340081,0.0004872658,0.0499688,0.0001532301,0.0001220576,0.002888333,0.00121006,0.03250411,0.8952551,0.0006923964,0.01656907,0.00007621537],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9918274,0.001166515,0.002568605,0.0002691657,0.00003408496,0.00001020195,0.0006373379,0.0000499525,0.003436887],"genre_scores_gemma":[0.9914764,0.001123716,0.002525152,0.000153079,0.00001187388,0.00002201204,0.001706954,0.00006276846,0.002918025],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002381438,"threshold_uncertainty_score":0.005841076,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02122621986680966,"score_gpt":0.3125698648355038,"score_spread":0.2913436449686941,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}