{"id":"W4416297982","doi":"10.1002/dvdy.70099","title":"Additive effects on craniofacial development upon conditional ablation of <scp>PDGFRα</scp> and <scp>SHP2</scp> in the mouse neural crest lineage","year":2025,"lang":"en","type":"article","venue":"Developmental Dynamics","topic":"Protein Tyrosine Phosphatases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Dental and Craniofacial Research; Anschutz Medical Campus, University of Colorado; National Institutes of Health; York University","keywords":"Neural crest; Craniofacial; Ablation; Lineage (genetic); Crest; Cell lineage","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001714041,0.0007996156,0.0003092961,0.0006978844,0.0002002403,0.0003862659,0.0003528501,0.0004926792,0.003279406],"category_scores_gemma":[0.0001134919,0.0004607003,0.0003855367,0.0001601442,0.0003948151,0.0001804897,0.0005884764,0.000899644,0.0005966082],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002638864,"about_ca_system_score_gemma":0.00024143,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008141668,"about_ca_topic_score_gemma":0.001800862,"domain_scores_codex":[0.9995199,0.00005103957,0.00005952534,0.00009155871,0.0001980654,0.00007985832],"domain_scores_gemma":[0.9996699,0.00004359311,0.0001026825,0.00003954824,0.00002055024,0.0001237529],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003874902,0.000008862727,0.00008896349,0.00001134619,0.000004057335,0.00005897599,0.00000388412,0.00002312391,0.9994674,0.00003616228,0.00001007148,0.0002483434],"study_design_scores_gemma":[0.00001695672,0.0002045069,0.007060858,0.000007148416,0.00004011866,0.0005785896,0.00003157695,0.0005661381,0.9899096,0.00002879059,0.001549491,0.000006164466],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939578,0.0006799389,0.002473,0.00006938948,0.00003369906,0.00003553568,0.0007433739,0.0001928677,0.001814396],"genre_scores_gemma":[0.9904634,0.0005034047,0.002330001,0.00006494762,0.00001207444,0.00007080344,0.0006861098,0.00008683577,0.005782365],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003279406,"threshold_uncertainty_score":0.01097077,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004841069874322541,"score_gpt":0.2245007150083747,"score_spread":0.2196596451340522,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}