{"id":"W4416300559","doi":"10.1101/2025.11.11.687869","title":"Comparative ASCL1 Interactome Analysis Reveals CDK2–Cyclin A2 as Suppressors of Differentiation in <i>MYCN</i> -Amplified Neuroblastoma","year":2025,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Neuroblastoma Research and Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Cancer Research UK Cambridge Institute, University of Cambridge; Medical Research Council; Wellcome Trust; Hutchison Whampoa Limited; National Institute for Health and Care Research; Terry Fox Foundation; UK Research and Innovation; Mohammed Bin Rashid University of Medicine and Health Sciences; Al Jalila Foundation; Neuroblastoma UK; Children's Cancer and Leukaemia Group; Cancer Research UK","keywords":"Transcription factor; Chromatin; Suppressor; Cellular differentiation; Interactome; Neuroblastoma; Transcription (linguistics); Cell cycle; Cell fate determination","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008282863,0.00016581,0.0001633016,0.0004638229,0.0001858486,0.000216688,0.0001373799,0.000145763,0.00199746],"category_scores_gemma":[0.0000939434,0.00008300836,0.0001994003,0.0002378093,0.0001457704,0.0001013979,0.0001402942,0.0001893946,0.0004836951],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003368523,"about_ca_system_score_gemma":0.0001039476,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001223368,"about_ca_topic_score_gemma":0.001945161,"domain_scores_codex":[0.9999201,0.000007382005,0.000005301059,0.00002826457,0.00002264694,0.00001628714],"domain_scores_gemma":[0.9999329,0.00001337987,0.00001835638,0.000007435997,0.000008262309,0.00001970354],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001414914,0.000008227295,0.001350651,0.00001779124,0.000007142498,0.00005018439,0.00001315248,0.00006471442,0.9975392,0.0000374334,0.00006003106,0.0007100991],"study_design_scores_gemma":[0.00001683713,0.00008930204,0.1319094,0.000005401759,0.00003291373,0.0007921542,0.00009040263,0.002786575,0.8609811,0.0001011648,0.003187038,0.000007696391],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960935,0.0005890173,0.0009658473,0.00004329228,0.000005552738,0.000005366097,0.00132654,0.00004038259,0.0009305801],"genre_scores_gemma":[0.9942592,0.0002614961,0.001246906,0.00004665842,0.000003684083,0.00001127976,0.002667906,0.0000225751,0.001480259],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00199746,"threshold_uncertainty_score":0.006682217,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02337449103222227,"score_gpt":0.3010628403093035,"score_spread":0.2776883492770812,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}