{"id":"W4416312322","doi":"10.3390/cancers17223693","title":"VHL Gene Restoration Supports RCC Reprogramming to iPSCs but Does Not Ensure Line Stability","year":2025,"lang":"en","type":"article","venue":"Cancers","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University Health Network; Lunenfeld-Tanenbaum Research Institute","funders":"","keywords":"Reprogramming; Induced pluripotent stem cell; Gene; Cell culture; Gene expression; Regulation of gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004168868,0.000212421,0.0002376645,0.0003033526,0.00019302,0.0006331315,0.0003302371,0.0004029131,0.001780197],"category_scores_gemma":[0.0004545832,0.0001155888,0.0002924337,0.0001737335,0.0003414768,0.0002829201,0.0002387403,0.0005962737,0.0006779985],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003926212,"about_ca_system_score_gemma":0.0003842078,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006049607,"about_ca_topic_score_gemma":0.0008092865,"domain_scores_codex":[0.9996904,0.00003484189,0.00004511951,0.00006933785,0.0001148205,0.00004548766],"domain_scores_gemma":[0.9995309,0.0001211144,0.0001134022,0.0001242666,0.00006266881,0.00004757014],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000521295,0.00003228424,0.0007314102,0.00005986887,0.000009647927,0.00009476414,0.00004232992,0.000419264,0.9924542,0.0006878059,0.000169973,0.005246213],"study_design_scores_gemma":[0.000008632319,0.00007058235,0.001633256,0.000006703305,0.00002468099,0.0002888692,0.0000206166,0.001535638,0.9902619,0.0001066584,0.006038617,0.000003896521],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9580451,0.001416937,0.0308994,0.0003285542,0.00009119054,0.0001225433,0.0009719141,0.001111312,0.007013198],"genre_scores_gemma":[0.9912447,0.000346869,0.004794235,0.00006466195,0.00001073548,0.00003696268,0.0008791812,0.0001094964,0.00251311],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001780197,"threshold_uncertainty_score":0.005955398,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01893705903779266,"score_gpt":0.3027189382544292,"score_spread":0.2837818792166366,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}