{"id":"W4416332014","doi":"10.1101/2025.11.14.688493","title":"The BMP ligand Gdf6a Regulates Development of the Zebrafish Craniofacial Skeleton in a Pharyngeal Arch-Specific Manner","year":2025,"lang":"","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Developmental Biology and Gene Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Zebrafish; Craniofacial; Morphogenesis; Craniofacial abnormality; Chondrogenesis; Skeleton (computer programming)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001490839,0.0008578727,0.0007207704,0.0001981789,0.0008166044,0.0001179601,0.001493679,0.001260117,0.00001444503],"category_scores_gemma":[0.0001559404,0.0006636261,0.0003431067,0.0007502279,0.0008108522,0.00001704125,0.001621335,0.0007877641,0.00001288278],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002961997,"about_ca_system_score_gemma":0.002308291,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001930263,"about_ca_topic_score_gemma":0.0001066556,"domain_scores_codex":[0.9951651,0.0004714303,0.001531282,0.001471269,0.0004497194,0.0009111674],"domain_scores_gemma":[0.9969216,0.00008506332,0.0007978173,0.001575509,0.0004574201,0.0001625785],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003678553,0.0002308477,0.02901671,0.0002568672,0.0004112993,0.000004994434,0.00007692689,0.00006952168,0.9686129,0.0002986381,0.0003951928,0.000258216],"study_design_scores_gemma":[0.0006893732,0.00003583346,0.3306217,0.0003579187,0.00003609189,3.934715e-8,0.000009903603,0.00002319554,0.6083013,0.000005114782,0.05943045,0.0004890084],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9917092,0.003571689,0.0001923681,0.0005599669,0.002349389,0.001405872,0.0001296592,0.00002759543,0.00005421187],"genre_scores_gemma":[0.9957874,0.001835852,0.001388345,0.0001518944,0.0003504264,0.0002347777,0.000004918136,0.0000595247,0.000186805],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3603116,"threshold_uncertainty_score":0.9995815,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007646216735876335,"score_gpt":0.2102274612571284,"score_spread":0.202581244521252,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}