{"id":"W4416332168","doi":"10.3390/genes16111388","title":"Distinct Morphokinetic Signature of Human Embryos with Chromosomal Mosaicism","year":2025,"lang":"en","type":"article","venue":"Genes","topic":"Developmental Biology and Gene Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Women's Health Research Institute; B.C. Women's Hospital & Health Centre; Women's College Hospital","funders":"","keywords":"Embryo; Ploidy; Embryogenesis; Chromosome; Signature (topology); Karyotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002452041,0.00017343,0.0001829359,0.0005857085,0.0001085076,0.0002489763,0.00009495093,0.0001947184,0.0008553406],"category_scores_gemma":[0.0004964792,0.00009205611,0.0001297452,0.0002011038,0.0001861404,0.000113123,0.0002239222,0.0001594442,0.0001434422],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001351736,"about_ca_system_score_gemma":0.0001161049,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003429583,"about_ca_topic_score_gemma":0.000301249,"domain_scores_codex":[0.9998385,0.00002549987,0.00002489183,0.0000410332,0.0000492174,0.00002078315],"domain_scores_gemma":[0.9997364,0.00004413283,0.0001421058,0.00001576812,0.00002842913,0.00003317457],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0008933814,0.00002404135,0.1300633,0.00005523579,0.00002996158,0.001595911,0.0001518364,0.0001210589,0.8601925,0.00009822327,0.00005105879,0.006723513],"study_design_scores_gemma":[0.00003735153,0.0009943492,0.8426874,0.00001772044,0.00009361669,0.01788747,0.0002824282,0.000791634,0.1357565,0.0001280853,0.001306551,0.00001689542],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988121,0.0003831052,0.0004736379,0.000009252307,0.000001962046,0.000008045064,0.00008630166,0.000007024152,0.0002185958],"genre_scores_gemma":[0.9988289,0.0002076299,0.0005328926,0.00001245506,0.000003536248,0.000009065218,0.0001920404,0.000003459464,0.0002099494],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008553406,"threshold_uncertainty_score":0.002861381,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003797565759560851,"score_gpt":0.2295374768569372,"score_spread":0.2257399110973764,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}