{"id":"W4416339432","doi":"10.1038/s41389-025-00586-x","title":"Pannexin 1 induces Rhabdomyosarcoma cell fusion by downregulating APOBEC2","year":2025,"lang":"en","type":"article","venue":"Oncogenesis","topic":"Muscle Physiology and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Children's Hospital of Eastern Ontario; University of Ottawa","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Cancer Research Society; University of Ottawa","keywords":"Downregulation and upregulation; Rhabdomyosarcoma; Cell culture; Ectopic expression; Cell fusion; Cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001311323,0.0001863069,0.000242392,0.000161645,0.0001194084,0.0001881566,0.0001397326,0.0002696963,0.001349678],"category_scores_gemma":[0.00009993746,0.0000924652,0.0001714512,0.00009966822,0.0001583574,0.0001257606,0.0001986737,0.0004895336,0.000347124],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002483553,"about_ca_system_score_gemma":0.0001874922,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001130832,"about_ca_topic_score_gemma":0.002124685,"domain_scores_codex":[0.9998406,0.00001729604,0.00001889104,0.00003970621,0.00004966937,0.00003381273],"domain_scores_gemma":[0.9999273,0.00001651916,0.00001727405,0.00001041905,0.00001006806,0.00001844048],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002697126,0.00001446912,0.00009761065,0.00001673172,0.000002487387,0.00002403978,0.00001161271,0.00003534903,0.9992135,0.00003921283,0.00004278645,0.0004752971],"study_design_scores_gemma":[0.00001593661,0.0003039781,0.005342018,0.000005896732,0.0000145434,0.0002248963,0.00004426212,0.001618798,0.9885484,0.00003325611,0.003843886,0.000004256251],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941917,0.0007905283,0.002200778,0.0001025129,0.00003252486,0.00004950962,0.0004438815,0.0001869989,0.002001565],"genre_scores_gemma":[0.9930906,0.0003817867,0.002163224,0.00006857825,0.000007254675,0.00004729064,0.0006929885,0.00002732877,0.003520862],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001349678,"threshold_uncertainty_score":0.004515171,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004246200418276048,"score_gpt":0.235197736522053,"score_spread":0.230951536103777,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}