{"id":"W4416340710","doi":"10.1002/ange.202513763","title":"Physically Masked Nanoflares for Accurate Biological Applications by Blocking Nucleases","year":2025,"lang":"de","type":"article","venue":"Angewandte Chemie","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"Natural Science Foundation of Hunan Province; National Natural Science Foundation of China","keywords":"Nucleic acid; Oligonucleotide; Biomolecule; DNA; Nanocages; In vivo; Decoy; Fluorescence","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002558686,0.0004551024,0.0001929755,0.0001167349,0.0001310074,0.000232752,0.0003154089,0.0005191596,0.0005113975],"category_scores_gemma":[0.0003492591,0.0002414111,0.0002009547,0.00006470083,0.0002604808,0.0003275181,0.0002843398,0.0004125519,0.0003239568],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003035812,"about_ca_system_score_gemma":0.0002831457,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002610706,"about_ca_topic_score_gemma":0.0004660253,"domain_scores_codex":[0.9998209,0.00002274659,0.00001788086,0.00005156826,0.00006282571,0.0000241676],"domain_scores_gemma":[0.9997924,0.00005159999,0.00007014206,0.00002279032,0.00004240005,0.00002056968],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000008724379,0.000003240589,0.00001388343,0.00001602829,0.000001149701,0.000007979908,0.000005352998,0.00005040336,0.9994184,0.00007367476,0.00001208977,0.0003891475],"study_design_scores_gemma":[0.000002608451,0.00004041499,0.0001105513,0.000001536366,0.00000246921,0.00003030952,0.000002578952,0.0008328243,0.9981387,0.00002344047,0.0008116941,0.000002886097],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9071515,0.002378908,0.08732362,0.0002663018,0.0001432299,0.0001042557,0.0001918631,0.0004901386,0.001950213],"genre_scores_gemma":[0.9276437,0.0007728399,0.06903797,0.0001303849,0.000021774,0.000112361,0.000179541,0.00005428853,0.002047121],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005191596,"threshold_uncertainty_score":0.00220263,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01369121360219424,"score_gpt":0.292327399863761,"score_spread":0.2786361862615668,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}