{"id":"W4416340962","doi":"10.1002/ange.202520677","title":"Frame‐Shifted Synthesis of Oligoheterocycles as a Platform for Molecular Design","year":2025,"lang":"de","type":"article","venue":"Angewandte Chemie","topic":"Catalytic Cross-Coupling Reactions","field":"Chemistry","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Vector Institute; Structural Genomics Consortium; University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Bifunctional; Leverage (statistics); Sustainable design; Production (economics); Variety (cybernetics); Sustainable production; Scheduling (production processes)","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002697326,0.0005018323,0.0007730043,0.0001790814,0.0002012958,0.0001374628,0.0005598421,0.0006794404,0.0003442941],"category_scores_gemma":[0.001810313,0.0005712232,0.0006020278,0.000408283,0.0003218665,0.0001247173,0.0001770342,0.0003697954,0.00007710983],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003334132,"about_ca_system_score_gemma":0.0004240116,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001527509,"about_ca_topic_score_gemma":0.000005571617,"domain_scores_codex":[0.9975641,0.000001779215,0.0007682652,0.0007032362,0.00032823,0.0006343945],"domain_scores_gemma":[0.9963199,0.001769939,0.0003689191,0.001096962,0.0002811293,0.0001630849],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004144137,0.0003361822,0.00006451095,0.001581361,0.001246066,0.00001924947,0.0002678788,0.0000550008,0.9906635,0.0004490335,0.003589081,0.001313682],"study_design_scores_gemma":[0.001058582,0.0000346675,0.00001442972,0.0010805,0.001450552,0.000007981967,0.0003197955,0.0002731842,0.9835513,0.005115409,0.006638352,0.0004553016],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9796041,0.006206782,0.005199523,0.0006810162,0.0006306994,0.0008328831,0.0007646284,0.0002259228,0.00585447],"genre_scores_gemma":[0.9954717,0.000328408,0.001354122,0.0001503775,0.0002163007,0.0003580526,0.0001664665,0.00009521584,0.00185932],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01586766,"threshold_uncertainty_score":0.9996739,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02027246707758825,"score_gpt":0.28878638967129,"score_spread":0.2685139225937018,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}