{"id":"W4416345602","doi":"10.1016/j.lfs.2025.124087","title":"CRISPR's impact on cancer: From fundamental models to clinical solutions","year":2025,"lang":"en","type":"article","venue":"Life Sciences","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sunnybrook Health Science Centre","funders":"Canadian Institutes of Health Research; Canadian Institute for Military and Veteran Health Research","keywords":"CRISPR; Genome engineering; Genome editing; Chimeric antigen receptor; Genome; Cancer; Synthetic biology; Prime (order theory)","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002669184,0.0005161862,0.0008599148,0.0007963167,0.0004626565,0.002315608,0.0007295387,0.001756013,0.002187832],"category_scores_gemma":[0.002070815,0.0002473703,0.0003720898,0.0004713825,0.002500319,0.001828955,0.001381417,0.003453532,0.0005803038],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001214467,"about_ca_system_score_gemma":0.001418095,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006337741,"about_ca_topic_score_gemma":0.0007234852,"domain_scores_codex":[0.9991679,0.0003181623,0.00004899142,0.00009937112,0.0002809302,0.00008461545],"domain_scores_gemma":[0.998838,0.0007435387,0.00006673674,0.00006876831,0.0001259581,0.0001570711],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003511636,0.0001160234,0.001206416,0.004696773,0.0001315331,0.0009113784,0.0005127735,0.002853442,0.04988325,0.3065405,0.07688032,0.5559164],"study_design_scores_gemma":[0.00004333182,0.0005001344,0.001203765,0.00167095,0.00009364047,0.002133366,0.0002645813,0.001081991,0.02182713,0.09527718,0.875843,0.00006097918],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00557929,0.8892071,0.02295689,0.05818293,0.002854133,0.00003318781,0.0001858186,0.0004360926,0.02056457],"genre_scores_gemma":[0.06489059,0.9064547,0.01091619,0.01049483,0.002278719,0.00005581986,0.0001574499,0.00008088643,0.004670659],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002669184,"threshold_uncertainty_score":0.01411617,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05879693736548466,"score_gpt":0.4492888807345983,"score_spread":0.3904919433691136,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}