{"id":"W4416356222","doi":"10.1016/j.conb.2025.103140","title":"Protein mechanism and therapeutic design in Parkinson's disease: A structural biology perspective","year":2025,"lang":"en","type":"article","venue":"Current Opinion in Neurobiology","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; McGill University","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; Fonds de recherche du Québec","keywords":"Neurodegeneration; Mechanism (biology); Perspective (graphical); Disease; Structural biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001060763,0.0008115306,0.0007683918,0.0005185839,0.0004087905,0.001532599,0.0007745771,0.001791154,0.002291666],"category_scores_gemma":[0.0005346669,0.0003997868,0.0005913957,0.0002944112,0.001490345,0.002890482,0.0007290238,0.00277053,0.001145554],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001202064,"about_ca_system_score_gemma":0.0008432998,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004475014,"about_ca_topic_score_gemma":0.0006650533,"domain_scores_codex":[0.9997846,0.00005774622,0.00001462938,0.00003544143,0.00006384936,0.00004359137],"domain_scores_gemma":[0.9998375,0.00005783448,0.00002876183,0.00001203697,0.00003768971,0.00002624485],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"theoretical_or_conceptual","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.000409195,0.0005731501,0.0006452781,0.005254952,0.0001749565,0.001235067,0.000454923,0.0135418,0.3092036,0.4158592,0.02483078,0.2278172],"study_design_scores_gemma":[0.0002993736,0.002247485,0.001046288,0.0009708485,0.0001629068,0.002467722,0.0003925697,0.00950746,0.08069788,0.1886653,0.713446,0.00009608724],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":"theoretical_or_conceptual","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.04702334,0.7402485,0.1073655,0.05832198,0.003709497,0.0003182274,0.000272696,0.0006146337,0.04212565],"genre_scores_gemma":[0.2341348,0.6750574,0.06378667,0.01116215,0.001581381,0.000379742,0.0003392306,0.0001595288,0.01339909],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002291666,"threshold_uncertainty_score":0.00872159,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04557074615178184,"score_gpt":0.3486516074243519,"score_spread":0.30308086127257,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}