{"id":"W4416356254","doi":"10.1097/paf.0000000000001050","title":"Designer Fentanyl Precursors Leading the Way to New Fentanyl Analogs—The Case of ortho-Methylfentanyl","year":2025,"lang":"en","type":"article","venue":"American Journal of Forensic Medicine & Pathology","topic":"Phosphodiesterase function and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"Provincial Health Services Authority","funders":"","keywords":"Fentanyl; Action (physics); MEDLINE; Designer drug","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008585211,0.000181172,0.0004425603,0.0001716735,0.0001231486,0.00000702619,0.0002643127,0.00006761449,0.00003625605],"category_scores_gemma":[0.0003458003,0.00009613058,0.0001549103,0.0004850161,0.0009100924,0.000006165508,0.00007178518,0.0002116523,0.000002511942],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000342638,"about_ca_system_score_gemma":0.0001407335,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001345907,"about_ca_topic_score_gemma":0.0003284197,"domain_scores_codex":[0.9984255,0.0003331404,0.0006267306,0.0002154419,0.0001592695,0.0002398632],"domain_scores_gemma":[0.9985144,0.0001504275,0.0005804989,0.000381743,0.0002381938,0.0001347321],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001213667,0.00008897988,0.00760709,0.00002265259,0.0004807719,0.0008249258,0.003272459,0.0004874071,0.4018155,0.001119178,0.07683231,0.506235],"study_design_scores_gemma":[0.01209758,0.03585888,0.06669143,0.0013744,0.003085396,0.08187878,0.06918406,0.0002316465,0.4890645,0.004397796,0.2346453,0.001490198],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.961309,0.001300206,0.02831527,0.007414691,0.0009177079,0.0001976687,0.000003179468,0.000004078076,0.0005381592],"genre_scores_gemma":[0.9929732,0.0001692926,0.001516354,0.003767099,0.0003514369,0.000004319958,0.000006703019,0.00001357583,0.001198005],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5047448,"threshold_uncertainty_score":0.3920091,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01076749933411801,"score_gpt":0.2867510365443195,"score_spread":0.2759835372102015,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}