{"id":"W4416359183","doi":"10.1080/21678421.2025.2589781","title":"How effective does a new drug for Amyotrophic Lateral Sclerosis need to be – the patient perspective: a letter in response to “Estimating the minimum important difference in the ALSFRS-R-instrument in people living with MND” published in vol. 26, pp. 249–258","year":2025,"lang":"en","type":"article","venue":"Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Diabetes Action Canada","keywords":"Amyotrophic lateral sclerosis; Drug; Drug trial; Riluzole; MEDLINE","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","scholarly_communication"],"consensus_categories":[],"category_scores_codex":[0.002437618,0.000651152,0.0009117934,0.0005843278,0.0004082159,0.0010694,0.000552336,0.0002174676,0.00001960975],"category_scores_gemma":[0.0009860606,0.0003201482,0.0001644736,0.00182796,0.0001728061,0.0006416421,0.0003323419,0.0008518091,0.000001624084],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001312406,"about_ca_system_score_gemma":0.0003110529,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.02372351,"about_ca_topic_score_gemma":0.05549511,"domain_scores_codex":[0.9942688,0.00136989,0.001100843,0.001240075,0.0008995204,0.001120891],"domain_scores_gemma":[0.997716,0.0007003427,0.0002581212,0.0007816058,0.0002917444,0.0002522073],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01092406,0.0008496981,0.7598534,0.0001761473,0.0001481751,0.00005198747,0.06610972,0.002953244,0.1457234,0.0004858346,0.003498075,0.009226227],"study_design_scores_gemma":[0.004091941,0.001108141,0.9725327,0.001604379,0.00004462077,0.000005424982,0.001886114,0.01741782,0.0004385663,0.000363623,0.00008514203,0.0004215606],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8149973,0.0003001407,0.000291373,0.1784549,0.0002571891,0.005633727,0.00002159511,0.00003665686,0.000007069013],"genre_scores_gemma":[0.9885253,0.00007736453,0.001469981,0.006626078,0.0002759958,0.002663655,0.00002308327,0.00006553593,0.0002730111],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2126793,"threshold_uncertainty_score":0.9999676,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01830887844012379,"score_gpt":0.2527435206361048,"score_spread":0.234434642195981,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}