{"id":"W4416359183","doi":"10.1080/21678421.2025.2589781","title":"How effective does a new drug for Amyotrophic Lateral Sclerosis need to be – the patient perspective: a letter in response to “Estimating the minimum important difference in the ALSFRS-R-instrument in people living with MND” published in vol. 26, pp. 249–258","year":2025,"lang":"en","type":"article","venue":"Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Diabetes Action Canada","keywords":"Amyotrophic lateral sclerosis; Drug; Drug trial; Riluzole; MEDLINE","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01422037,0.000920886,0.002690313,0.0009130783,0.003886497,0.004606469,0.002132258,0.03527591,0.005900017],"category_scores_gemma":[0.05916341,0.0006559066,0.001621218,0.0008064858,0.004834553,0.007750314,0.001442501,0.03777038,0.006403712],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.004351985,"about_ca_system_score_gemma":0.004982385,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004973356,"about_ca_topic_score_gemma":0.00926737,"domain_scores_codex":[0.9914819,0.003691987,0.001652467,0.0009033412,0.001713785,0.0005565568],"domain_scores_gemma":[0.9549736,0.02652707,0.002761649,0.0007692841,0.0103734,0.004594935],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003778872,0.00007623477,0.001141129,0.0003465711,0.00009654594,0.0004630936,0.0002465808,0.00006126617,0.000304212,0.001544413,0.9654366,0.02990537],"study_design_scores_gemma":[0.0007652004,0.0008414431,0.003987253,0.001767022,0.0002509287,0.00320271,0.00188999,0.0005268811,0.0008119816,0.01213267,0.973473,0.0003510609],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.0002203307,0.003070828,0.00005252573,0.9884351,0.007733672,0.000005041443,0.00003320544,0.000009943739,0.0004393708],"genre_scores_gemma":[0.002810649,0.002837416,0.000186594,0.9769657,0.01643194,0.00001473732,0.00002265756,0.00001524593,0.0007149416],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.03527591,"threshold_uncertainty_score":0.07520539,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01830887844012379,"score_gpt":0.2527435206361048,"score_spread":0.234434642195981,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}