{"id":"W4416371045","doi":"10.1093/stcltm/szaf056","title":"Teratoma-free cartilage regeneration using <i>p21</i> −/− iPSCs engineered with iCasp9","year":2025,"lang":"en","type":"article","venue":"Stem Cells Translational Medicine","topic":"Osteoarthritis Treatment and Mechanisms","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; Alberta Bone and Joint Health Institute","funders":"Canadian Institutes of Health Research; Canada Foundation for Innovation","keywords":"Induced pluripotent stem cell; Cartilage; Regeneration (biology); Regenerative medicine; Articular cartilage; Articular cartilage damage","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003110921,0.0004819149,0.0002716416,0.0002895912,0.0001906819,0.0003494516,0.000423151,0.0005912083,0.001551621],"category_scores_gemma":[0.0001523443,0.0001751469,0.0004805837,0.0002066631,0.000427008,0.0002838225,0.0002354241,0.001100684,0.0009628329],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002120377,"about_ca_system_score_gemma":0.000251103,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004626801,"about_ca_topic_score_gemma":0.0004599171,"domain_scores_codex":[0.9996717,0.00001847824,0.00006399984,0.00009071478,0.0001167211,0.00003846094],"domain_scores_gemma":[0.9996566,0.00004368612,0.0001462843,0.00005904827,0.00004153884,0.00005282972],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005461039,0.00002505796,0.0001259877,0.00005341213,0.0000058126,0.0001053964,0.00002217079,0.0001515441,0.9979177,0.0002056274,0.00008501828,0.00124765],"study_design_scores_gemma":[0.000009039149,0.0001057634,0.0007502123,0.000008875651,0.00001492736,0.0002541542,0.0000129145,0.0007758954,0.9956109,0.00003553309,0.002417911,0.000003866857],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9273296,0.001655642,0.05328942,0.0002335307,0.0002900375,0.0002958107,0.004402759,0.001217499,0.01128567],"genre_scores_gemma":[0.974565,0.001070118,0.01352092,0.0001052241,0.00002440414,0.0001720157,0.002736156,0.000239121,0.007567054],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001551621,"threshold_uncertainty_score":0.00519073,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01548757687377995,"score_gpt":0.2428850458733775,"score_spread":0.2273974689995976,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}