{"id":"W4416385027","doi":"10.1101/2025.11.19.689184","title":"Spatiotemporal-multimodal integration reveals BCG-induced skin-blood crosstalk","year":2025,"lang":"","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Immune responses and vaccinations","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University; Prevention of Organ Failure; University of British Columbia","funders":"","keywords":"Vaccination; Immune system; Tuberculosis; Crosstalk; Immunity; BCG vaccine; Suppressor; Mycobacterium tuberculosis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","sts","research_integrity","insufficient_payload"],"consensus_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"category_scores_codex":[0.001987092,0.001899179,0.002084459,0.001356189,0.001690044,0.000585196,0.001743869,0.003868023,0.001074262],"category_scores_gemma":[0.001570918,0.002099742,0.000964078,0.001592819,0.0003911431,0.0005516398,0.00137526,0.003442607,0.0008636425],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007318972,"about_ca_system_score_gemma":0.003018716,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009782788,"about_ca_topic_score_gemma":0.00003272927,"domain_scores_codex":[0.9907838,0.001806352,0.002611393,0.002686706,0.0002988032,0.001813001],"domain_scores_gemma":[0.9914424,0.0006502261,0.001889131,0.003473032,0.002297745,0.0002474309],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006202473,0.001284208,0.002611365,0.0005166774,0.001807587,0.00005265717,0.00009635874,0.00002320497,0.9886136,0.003484901,0.000812804,0.00007640247],"study_design_scores_gemma":[0.003965416,0.0004024761,0.1628673,0.001633955,0.0010349,2.585295e-7,0.00003119187,0.0001698184,0.8145729,0.000006478276,0.01340379,0.0019115],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9755709,0.006456831,0.003282889,0.001012429,0.007936193,0.003148974,0.001864463,0.000613866,0.0001134767],"genre_scores_gemma":[0.9935222,0.001745657,0.001919019,0.0003499857,0.0004550823,0.000611911,0.00001483751,0.0001920971,0.001189217],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1740406,"threshold_uncertainty_score":0.9999143,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01388057113622529,"score_gpt":0.2499291434725908,"score_spread":0.2360485723363656,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}