{"id":"W4416387766","doi":"10.1016/j.annonc.2025.09.127","title":"LBA108 Durvalumab (D) in combination with Bacillus Calmette-Guérin (BCG) for BCG-naïve, high-risk non-muscle-invasive bladder cancer (NMIBC): Final analysis of the phase III, open-label, randomised POTOMAC trial","year":2025,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Bladder and Urothelial Cancer Treatments","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval","funders":"Cilag; Institut National Du Cancer; Sanofi; AstraZeneca; Pfizer","keywords":"Durvalumab; Bladder cancer; Bacillus (shape); Phases of clinical research; Cancer; Clinical trial","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001037975,0.0009589375,0.002119122,0.0002988179,0.0002325722,0.0008551078,0.0008778342,0.0008727076,0.004034926],"category_scores_gemma":[0.0009228082,0.0004093288,0.001306956,0.0003505846,0.0007618291,0.001044664,0.0003700942,0.00259494,0.0009308192],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008719467,"about_ca_system_score_gemma":0.0007904054,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001725054,"about_ca_topic_score_gemma":0.005063894,"domain_scores_codex":[0.9996575,0.00017248,0.00001542941,0.00005370452,0.00002587982,0.00007509506],"domain_scores_gemma":[0.9996328,0.00008829268,0.00006540219,0.00003041021,0.00001783615,0.0001651253],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8976189,0.005122288,0.001800345,0.001302589,0.001740006,0.00009620726,0.0001119797,0.000915702,0.00840241,0.000307643,0.003265281,0.07931658],"study_design_scores_gemma":[0.8913271,0.09738225,0.005635238,0.0001002088,0.0008172531,0.0001809926,0.00006223081,0.0008789115,0.001004724,0.0002869615,0.002298826,0.0000252771],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9839129,0.009758677,0.000498036,0.0006601612,0.0003938533,0.0008332484,0.001082565,0.0001471441,0.00271337],"genre_scores_gemma":[0.9892523,0.003738588,0.0009253438,0.0007853474,0.0001645214,0.0006085467,0.001667501,0.00002822413,0.002829639],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004034926,"threshold_uncertainty_score":0.01349819,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08227437248820987,"score_gpt":0.4244943737016463,"score_spread":0.3422200012134364,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}