{"id":"W4416389965","doi":"10.1139/jpn-2025-0194","title":"Discussion: Genome-wide DNA methylation profiling of blood samples from patients with major depressive disorder: correlation with symptom heterogeneity","year":2025,"lang":"en","type":"article","venue":"Journal of Psychiatry and Neuroscience","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"","keywords":"Correlation; DNA methylation; DNA; Disease; Gene expression profiling; Profiling (computer programming)","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001313957,0.0002037768,0.0003864283,0.0004881702,0.0003615208,0.0008210529,0.0003713971,0.000579888,0.001323846],"category_scores_gemma":[0.003799497,0.00009912853,0.0003226471,0.0006117813,0.0003156749,0.0002654592,0.0003858368,0.0005176863,0.0001923966],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002319004,"about_ca_system_score_gemma":0.0002527611,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001223153,"about_ca_topic_score_gemma":0.002142596,"domain_scores_codex":[0.9991709,0.0001824766,0.000119063,0.0002785245,0.0001486791,0.000100378],"domain_scores_gemma":[0.9980516,0.001067691,0.000389051,0.0001428035,0.0002133028,0.0001354522],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0006753257,0.00003012271,0.9639728,0.00008634915,0.0002765055,0.0002661144,0.0003538121,0.000117577,0.02312195,0.0001069083,0.0008604852,0.01013204],"study_design_scores_gemma":[0.00001959965,0.0001421099,0.9925393,0.00001963698,0.0001412217,0.0014008,0.0003400903,0.0002261827,0.003728804,0.0003085525,0.001123988,0.000009617593],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929631,0.001445111,0.001162678,0.001874323,0.00007162643,0.00002145394,0.001386511,0.00003208025,0.001043136],"genre_scores_gemma":[0.9977826,0.0001650515,0.0003649315,0.0007533184,0.0000629906,0.00001188127,0.0006202848,0.000007780389,0.0002311484],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001323846,"threshold_uncertainty_score":0.006948948,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006440307796780557,"score_gpt":0.2372985901015115,"score_spread":0.2308582823047309,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}