{"id":"W4416391673","doi":"10.1016/j.annonc.2025.09.067","title":"LBA55 START-001: Initial phase II clinical activity of invikafusp alfa, a first-in-class T cell receptor (TCR) β-chain-targeted bispecific antibody as monotherapy in patients with antigen-rich solid tumors resistant to immune checkpoint blockade (ICB)","year":2025,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Bispecific antibody; Blockade; Immune checkpoint; Antibody; T cell; Immune system; Immunotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009049368,0.00124746,0.001140155,0.0003987587,0.0003455151,0.001038273,0.0008573519,0.0008239293,0.004324906],"category_scores_gemma":[0.0004479824,0.0003924331,0.001067462,0.0003474953,0.0005747152,0.0005704386,0.0003410451,0.003525648,0.00138412],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001158822,"about_ca_system_score_gemma":0.001458419,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002847657,"about_ca_topic_score_gemma":0.008166489,"domain_scores_codex":[0.9997806,0.00004728856,0.000008274581,0.0000305076,0.00002482553,0.0001086022],"domain_scores_gemma":[0.9997659,0.00002834328,0.00003011593,0.00001888397,0.00001672181,0.0001399845],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.1847661,0.03990871,0.008630756,0.001957566,0.002186563,0.0006973909,0.000810926,0.009246576,0.1924152,0.00232691,0.04136875,0.5156847],"study_design_scores_gemma":[0.3219269,0.5264776,0.04358665,0.0003571059,0.00182157,0.002097444,0.0002716853,0.009360271,0.04639038,0.001273856,0.04627492,0.0001615193],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9729906,0.006789857,0.002244783,0.001649039,0.0003408286,0.001714895,0.003740303,0.0007195153,0.009810248],"genre_scores_gemma":[0.9722601,0.004424444,0.002768513,0.001665359,0.000122481,0.001123221,0.009429943,0.0001319333,0.008074027],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004324906,"threshold_uncertainty_score":0.01446825,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06070611630248961,"score_gpt":0.4322783958404597,"score_spread":0.3715722795379701,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}