{"id":"W4416391724","doi":"10.1016/j.annonc.2025.09.076","title":"LBA64 Safety and performance of a multi-cancer early detection (MCED) test in an intended-use population: Initial results from the registrational PATHFINDER II study","year":2025,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Statistical Methods in Clinical Trials","field":"Mathematics","cited_by":7,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"Pathfinder; Test (biology); Test site","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01451675,0.000960222,0.001604788,0.0006375824,0.0004050543,0.001597933,0.0008810121,0.001541001,0.001993125],"category_scores_gemma":[0.03338043,0.0003936671,0.002144082,0.0008467169,0.001248498,0.001289707,0.0008428415,0.002282061,0.0006039131],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007772938,"about_ca_system_score_gemma":0.001167887,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001055436,"about_ca_topic_score_gemma":0.0007937904,"domain_scores_codex":[0.989164,0.008397986,0.0003391251,0.0007724674,0.001030931,0.0002955394],"domain_scores_gemma":[0.9723044,0.01709463,0.005324862,0.003070388,0.001315552,0.0008900893],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.745773,0.004571321,0.1648583,0.0007177813,0.004480171,0.0001688239,0.0003854477,0.00175543,0.004551902,0.0005017719,0.002454837,0.06978116],"study_design_scores_gemma":[0.1133849,0.3149333,0.5253732,0.0002872463,0.01302262,0.0006684675,0.0004005958,0.01105525,0.009788997,0.002930619,0.007901217,0.0002534676],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9924362,0.00198494,0.001366616,0.0004520241,0.00006722027,0.0002520391,0.001724737,0.00007882985,0.001637322],"genre_scores_gemma":[0.9962993,0.0004307024,0.001050308,0.0003003468,0.00009039006,0.0001188486,0.0010002,0.00003122522,0.0006786994],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01451675,"threshold_uncertainty_score":0.07677281,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.6448445048999395,"score_gpt":0.6030298954929485,"score_spread":0.041814609406991,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}