{"id":"W4416391787","doi":"10.1016/j.annonc.2025.09.028","title":"LBA18 Trastuzumab deruxtecan (T-DXd) + pertuzumab (P) vs taxane + trastuzumab + pertuzumab (THP) for patients (pts) with HER2+ advanced/metastatic breast cancer (a/mBC): Additional analyses of DESTINY-Breast09 in key subgroups of interest","year":2025,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"HER2/EGFR in Cancer Research","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":false,"ca_institutions":"AstraZeneca (Canada)","funders":"AstraZeneca","keywords":"Pertuzumab; Taxane; Trastuzumab; Breast cancer; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001143008,0.0004186939,0.0008621439,0.000274589,0.0002098009,0.0007619383,0.0004116838,0.0006217915,0.005168403],"category_scores_gemma":[0.001716717,0.0001725248,0.001717955,0.0003457962,0.0003091626,0.0009453047,0.0003762962,0.001254939,0.0003927724],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006786382,"about_ca_system_score_gemma":0.0007678633,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001185252,"about_ca_topic_score_gemma":0.003650537,"domain_scores_codex":[0.9993586,0.0002689553,0.00003441164,0.0001206768,0.0000416396,0.0001756786],"domain_scores_gemma":[0.9992113,0.0003666075,0.0001224878,0.00004163012,0.000026024,0.0002320029],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.7954261,0.002901683,0.1226917,0.000320569,0.003228918,0.0002400057,0.0002285364,0.001222768,0.007950069,0.0003688423,0.001995056,0.06342573],"study_design_scores_gemma":[0.09323566,0.2361059,0.6323299,0.0001595089,0.01049519,0.0008250789,0.0009487927,0.006426515,0.006039496,0.001762755,0.01157938,0.00009184109],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971145,0.001040168,0.00008826962,0.0002451927,0.00004341256,0.00004923108,0.0005049327,0.000008950414,0.0009052447],"genre_scores_gemma":[0.9978515,0.00027234,0.0001374837,0.0001422338,0.00006792578,0.00004058239,0.0005991043,0.00000376281,0.0008851051],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005168403,"threshold_uncertainty_score":0.01729006,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.147782217334356,"score_gpt":0.4590405512808375,"score_spread":0.3112583339464815,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}