{"id":"W4416397979","doi":"10.1002/bit.70111","title":"AAV Assembled Capsids Are Produced in Cells Blocked From Cell Cycle Progression","year":2025,"lang":"en","type":"article","venue":"Biotechnology and Bioengineering","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; National Research Council Canada","funders":"National Research Council Canada","keywords":"Capsid; HEK 293 cells; Cell cycle progression; Cell cycle; Virus; Gene delivery; Cell; DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001411535,0.0001715342,0.0001741146,0.0002146385,0.00005359755,0.00001600723,0.0002143333,0.0005288881,0.000004626409],"category_scores_gemma":[0.00002542615,0.0001632367,0.00003304916,0.000282964,0.00006489382,0.000003202228,0.0001880041,0.0002499511,0.000003914321],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001986132,"about_ca_system_score_gemma":0.00004540543,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002077296,"about_ca_topic_score_gemma":0.0001003233,"domain_scores_codex":[0.998966,0.00003052,0.0001676703,0.0004586523,0.00006691903,0.000310172],"domain_scores_gemma":[0.9995168,0.00001008994,0.00003691741,0.000373512,0.00002374623,0.00003896073],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002196156,0.00006463453,0.003668073,0.00003570143,0.00003009112,0.000009643718,0.000008930347,0.000124297,0.991698,0.00001301236,0.00007151913,0.004056535],"study_design_scores_gemma":[0.000710841,0.000337358,0.001487974,0.00005788169,0.00000793209,0.000001231183,0.00004256739,0.0008159398,0.9955291,0.00005022363,0.0007926171,0.0001663701],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994827,0.003493925,0.0002207923,0.0009391443,0.00012477,0.0002712,0.000008819013,0.00007296469,0.0000414091],"genre_scores_gemma":[0.9983688,0.0005857283,0.0007743998,0.0000535436,0.00004458381,0.00004059674,0.00002093855,0.00001704471,0.00009434813],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003890165,"threshold_uncertainty_score":0.6656598,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005553678132973366,"score_gpt":0.2535580145353908,"score_spread":0.2480043364024175,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}