{"id":"W4416397979","doi":"10.1002/bit.70111","title":"AAV Assembled Capsids Are Produced in Cells Blocked From Cell Cycle Progression","year":2025,"lang":"en","type":"article","venue":"Biotechnology and Bioengineering","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; National Research Council Canada","funders":"National Research Council Canada","keywords":"Capsid; HEK 293 cells; Cell cycle progression; Cell cycle; Virus; Gene delivery; Cell; DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002527775,0.0001945757,0.0003334361,0.000176073,0.0002041932,0.0006160255,0.0002164604,0.0002647563,0.0008371414],"category_scores_gemma":[0.0004107945,0.0001969759,0.0002463921,0.0001783568,0.0002312161,0.0002918268,0.0002418112,0.000674428,0.00054889],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003912443,"about_ca_system_score_gemma":0.0002590728,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001899013,"about_ca_topic_score_gemma":0.001475328,"domain_scores_codex":[0.9996438,0.00004516347,0.00004099807,0.00009894362,0.000110057,0.00006093648],"domain_scores_gemma":[0.9996728,0.0001007852,0.00006566587,0.00004478715,0.00007332415,0.00004270459],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005947895,0.00001335468,0.0002419507,0.00001525802,0.00000349847,0.0000181271,0.00003190886,0.00004428484,0.9989781,0.00007229967,0.00002763713,0.0004942049],"study_design_scores_gemma":[0.000008679141,0.0001636463,0.005293265,0.000005615968,0.000008979026,0.00006938239,0.00004440871,0.001514624,0.9902619,0.00006641623,0.002556602,0.000006567768],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9845043,0.0008094589,0.01217989,0.00006181103,0.00005449947,0.00005145145,0.0006500157,0.0001280234,0.001560576],"genre_scores_gemma":[0.9832449,0.0003688186,0.008776587,0.00009433002,0.00000856633,0.00009393234,0.002243297,0.0001099121,0.005059696],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001899013,"threshold_uncertainty_score":0.003775895,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005553678132973366,"score_gpt":0.2535580145353908,"score_spread":0.2480043364024175,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}