{"id":"W4416398249","doi":"10.20944/preprints202511.1346.v1","title":"<em>Lentinula edodes </em>Cultured Extract Treated Mesenchymal-Derived Extracellular Vesicle Modulated Breast Cancer Stem Cells and Reprogramming of microRNAs","year":2025,"lang":"","type":"preprint","venue":"Preprints.org","topic":"Polysaccharides and Plant Cell Walls","field":"Agricultural and Biological Sciences","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Mesenchymal stem cell; Reprogramming; Cancer stem cell; Stem cell; microRNA; Cancer; Cancer cell; Breast cancer; In vitro","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001798547,0.0003979317,0.0002125053,0.0002187333,0.0001109212,0.0002506856,0.0001540292,0.0002858273,0.00172603],"category_scores_gemma":[0.00008951717,0.00009245172,0.0002428535,0.0001868264,0.0002095967,0.0001968758,0.0001502956,0.0005362455,0.0006668405],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002148412,"about_ca_system_score_gemma":0.00016079,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005415487,"about_ca_topic_score_gemma":0.0005074034,"domain_scores_codex":[0.9998863,0.00001767049,0.00001264285,0.00002746356,0.00003151398,0.00002451991],"domain_scores_gemma":[0.9999444,0.0000102532,0.00001858017,0.000007244208,0.000008651456,0.00001069414],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009173907,0.00002805062,0.00007994393,0.00006583877,0.00000408324,0.00003828348,0.0000177377,0.00006475286,0.9975227,0.0001597247,0.0001117242,0.001815504],"study_design_scores_gemma":[0.000006472041,0.00009630138,0.0007646694,0.00000651669,0.000007577993,0.00005877126,0.000009258366,0.0002983148,0.9951406,0.0000317127,0.003576832,0.000002920899],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9603469,0.00344881,0.02054236,0.0003490771,0.0002527596,0.0002382164,0.003328583,0.0006886843,0.01080464],"genre_scores_gemma":[0.9666765,0.001521243,0.01507207,0.0001766025,0.00002918936,0.0002273817,0.003366362,0.0001552329,0.0127754],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00172603,"threshold_uncertainty_score":0.00577414,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04751172359277189,"score_gpt":0.267616177023248,"score_spread":0.2201044534304761,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}