{"id":"W4416398252","doi":"10.1093/hmg/ddag031","title":"MeCP2 NID interaction with RNA: Implications for Rett Syndrome-Relevant Protein Regulation","year":2025,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre for Addiction and Mental Health; University of Alberta; University of Victoria","funders":"","keywords":"MECP2; Rett syndrome; RNA-binding protein; RNA; Missense mutation; Zinc finger; Binding domain; Mutation; Gene; Binding site","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001590825,0.0003087534,0.0002069429,0.0001531398,0.0002332088,0.0003647302,0.0002263394,0.0003653306,0.001013411],"category_scores_gemma":[0.0002215258,0.0001305367,0.0002289472,0.00007368424,0.000304153,0.0002378465,0.0002049907,0.0002469914,0.0003342015],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000445956,"about_ca_system_score_gemma":0.0001774077,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009007787,"about_ca_topic_score_gemma":0.001340714,"domain_scores_codex":[0.9998647,0.00002440157,0.00001128773,0.0000464505,0.0000320471,0.00002105936],"domain_scores_gemma":[0.9999065,0.00002646407,0.0000259253,0.00001036092,0.000009026187,0.00002175995],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003038286,0.000005886578,0.000606519,0.00002528066,0.000003253274,0.0002728409,0.00001273406,0.00006462647,0.9979789,0.0003331335,0.00002025827,0.000646418],"study_design_scores_gemma":[0.000007182948,0.00006593528,0.01511078,0.000007890475,0.00001233943,0.00112408,0.0000462969,0.001678491,0.9794124,0.0003232056,0.002203558,0.000007827906],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9766584,0.006768641,0.0108409,0.0003628577,0.0000700245,0.00002510587,0.0002511843,0.000115502,0.004907388],"genre_scores_gemma":[0.9950427,0.0004984466,0.002798093,0.00008200474,0.00001000643,0.0000118571,0.0001555602,0.00001060632,0.001390841],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001013411,"threshold_uncertainty_score":0.003390133,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0105794854874843,"score_gpt":0.2667181378529558,"score_spread":0.2561386523654716,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}