{"id":"W4416398262","doi":"10.1002/advs.202511780","title":"A Virtual Clinical Trial of Psychedelics to Treat Patients With Disorders of Consciousness","year":2025,"lang":"en","type":"article","venue":"Advanced Science","topic":"Psychedelics and Drug Studies","field":"Psychology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Fonds Léon Fredericq; Koning Boudewijnstichting; Fundação Bial; Fonds Wetenschappelijk Onderzoek; Fonds De La Recherche Scientifique - FNRS; Mind Science Foundation","keywords":"Psilocybin; Persistent vegetative state; Wakefulness; Consciousness; Functional magnetic resonance imaging; Minimally conscious state; Clinical trial; Unconsciousness; Consciousness Disorders","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002033795,0.000319664,0.0004195769,0.000113842,0.0001238508,0.0002779321,0.0002937521,0.0002760658,0.003007624],"category_scores_gemma":[0.0005387604,0.0000994272,0.000417271,0.00006506513,0.0002664101,0.0001604225,0.0002338219,0.000473606,0.0001798364],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002648399,"about_ca_system_score_gemma":0.0005176296,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007586317,"about_ca_topic_score_gemma":0.001096948,"domain_scores_codex":[0.9999583,0.00001932459,0.000002505572,0.000008065987,0.000003908868,0.000007943351],"domain_scores_gemma":[0.9998676,0.00006446309,0.00001613342,0.0000134324,0.000008110941,0.00003039012],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.2165516,0.02822425,0.008332765,0.00132225,0.001784769,0.0008347845,0.0003153472,0.413865,0.048226,0.00946347,0.00905921,0.2620206],"study_design_scores_gemma":[0.09036183,0.2412675,0.01466656,0.0001417357,0.001205056,0.000586115,0.0002392378,0.6072919,0.01871021,0.01300963,0.01235876,0.000161401],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9911615,0.00041185,0.004888165,0.0003154025,0.0001198548,0.0003641568,0.0003768432,0.0001130656,0.002249201],"genre_scores_gemma":[0.9965425,0.000192367,0.002042758,0.0001058429,0.0000134191,0.0003357259,0.0001829837,0.000005194078,0.0005791396],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003007624,"threshold_uncertainty_score":0.0100615,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02667305767991763,"score_gpt":0.4169063813810029,"score_spread":0.3902333237010853,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}