{"id":"W4416398875","doi":"10.1016/j.dmd.2025.100203","title":"Characterization of genetically modified human embryonic kidney 293 cells lacking equilibrative nucleoside transporter subtype 2, or both subtypes 1 and 2, and the impact of their loss on sensitivity to chemotherapeutic purine/pyrimidine analogs","year":2025,"lang":"en","type":"article","venue":"Drug Metabolism and Disposition","topic":"Adenosine and Purinergic Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; University of Alberta","keywords":"Nucleoside; Nucleoside transporter; Embryonic stem cell; HEK 293 cells; Transporter; Nucleoside analogue; Endogeny","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002028168,0.0001615101,0.0002755792,0.00006621511,0.00007394856,0.00002306594,0.00004633874,0.00007041767,0.000006786045],"category_scores_gemma":[0.00001163273,0.0001010871,0.00006415054,0.0001098535,0.0001525626,0.00001304095,0.00003699342,0.00005475733,8.35232e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000003509211,"about_ca_system_score_gemma":0.00004042058,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008498997,"about_ca_topic_score_gemma":0.000008709078,"domain_scores_codex":[0.9992477,0.0001183109,0.0002017067,0.0002417051,0.00006584819,0.0001247251],"domain_scores_gemma":[0.9995901,0.0000360845,0.0001009123,0.0001506237,0.0000575566,0.00006470003],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001343569,0.00006201359,0.0006608295,0.00005998555,0.0001129338,0.000001066474,0.0004765153,0.00006750459,0.9953492,0.001299913,0.0000335523,0.0005329761],"study_design_scores_gemma":[0.001573443,0.0001468393,0.1371432,0.00007613895,0.0001393847,0.000005201634,0.00005366926,0.0007279515,0.8596703,0.0002721769,0.00005204467,0.0001395646],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966385,0.0005847717,0.001972268,0.0003113531,0.00002464808,0.0002685818,0.0001064667,0.000005178506,0.00008824425],"genre_scores_gemma":[0.9987979,0.0004982277,0.00003995226,0.0003632319,0.00005636742,0.000006502674,0.0001554752,0.00001193475,0.0000704055],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1364824,"threshold_uncertainty_score":0.4122213,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007886212375152102,"score_gpt":0.253001528504997,"score_spread":0.2451153161298449,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}