{"id":"W4416400017","doi":"10.1016/j.jare.2025.11.020","title":"Peptide IRW upregulates ACE2 in spontaneously hypertensive rats via dopamine/D1R signaling pathway","year":2025,"lang":"en","type":"article","venue":"Journal of Advanced Research","topic":"Renin-Angiotensin System Studies","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Downregulation and upregulation; Signal transduction; In vivo; Peptide; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002342168,0.0002400226,0.001064084,0.001214112,0.0001791661,0.00004182102,0.0002790014,0.0001405467,0.00002192569],"category_scores_gemma":[0.002649357,0.0001777316,0.0002488151,0.001191824,0.0002311111,0.0001960749,0.000180816,0.001229178,0.00002333642],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005313949,"about_ca_system_score_gemma":0.000520848,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003279021,"about_ca_topic_score_gemma":0.00005861572,"domain_scores_codex":[0.9962779,0.0004186849,0.001020669,0.0003270702,0.001260031,0.000695612],"domain_scores_gemma":[0.9947035,0.001433478,0.0002767393,0.0003839961,0.002996165,0.0002061306],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002587666,0.0002135675,0.008567425,0.0001501732,0.0003627737,0.01166989,0.0009212002,0.001563067,0.9524226,0.00004636757,0.0034128,0.01808244],"study_design_scores_gemma":[0.01384659,0.005088817,0.08783697,0.01570549,0.0002455138,0.01793952,0.0115742,0.001105385,0.8115857,0.002989515,0.03125021,0.0008321082],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9836263,0.00876612,0.0001590867,0.003890279,0.0004200963,0.00060615,0.000002073631,0.00001881197,0.002511102],"genre_scores_gemma":[0.990958,0.0004144797,0.003554611,0.0001431796,0.0003346885,0.000009949272,0.000001598231,0.00003512753,0.004548415],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.140837,"threshold_uncertainty_score":0.7247683,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03596253228613049,"score_gpt":0.3601902213726466,"score_spread":0.3242276890865161,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}