{"id":"W4416402674","doi":"10.3389/fneur.2025.1664458","title":"Prognostic and predictive determinants in high-grade gliomas: integrating tumor-intrinsic biology with patient and system-level factors","year":2025,"lang":"en","type":"article","venue":"Frontiers in Neurology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University; McGill University","funders":"","keywords":"Oligodendroglioma; Mechanism (biology); Radiogenomics; Glioblastoma; Precision medicine; Personalized medicine; Astrocytoma; Narrative review","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00192066,0.0004629216,0.000810811,0.001055524,0.0001923617,0.001583158,0.0003934582,0.0003726407,0.001236639],"category_scores_gemma":[0.005583144,0.0001181611,0.0008092957,0.001238709,0.0003751202,0.0009827389,0.0005265549,0.0009752575,0.0002686836],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005742837,"about_ca_system_score_gemma":0.001456333,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002128863,"about_ca_topic_score_gemma":0.00450277,"domain_scores_codex":[0.999376,0.0002503679,0.0001068439,0.0000904105,0.0001302691,0.00004615673],"domain_scores_gemma":[0.9978157,0.001269254,0.0004096583,0.00005677108,0.0003771834,0.00007134889],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.0006870024,0.00006965448,0.2434952,0.01590084,0.002588071,0.0009069677,0.0009132498,0.004193034,0.003035152,0.008855042,0.01438778,0.704968],"study_design_scores_gemma":[0.00009060113,0.001008388,0.5028321,0.0251909,0.01250836,0.008291547,0.002895253,0.009479462,0.004898358,0.04899129,0.3835285,0.000285106],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.05619373,0.9159858,0.01077967,0.009781678,0.0005849678,0.00006575154,0.001648616,0.00007072952,0.004889088],"genre_scores_gemma":[0.4317454,0.5530286,0.009493724,0.00146404,0.001159072,0.0000764748,0.002063636,0.0000282717,0.0009407799],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.002128863,"threshold_uncertainty_score":0.01015753,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008081192917638895,"score_gpt":0.2276195882246228,"score_spread":0.2195383953069839,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}