{"id":"W4416404834","doi":"10.1016/j.bbrc.2025.153007","title":"Association of endogenous hormones with major depressive disorder phenotype: A systematic review and meta-analysis of drug-free case and control cross-sectional study","year":2025,"lang":"en","type":"article","venue":"Biochemical and Biophysical Research Communications","topic":"Menopause: Health Impacts and Treatments","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"Innovation Cluster (Canada)","funders":"Council of Scientific and Industrial Research, India; Indian Council of Medical Research","keywords":"Major depressive disorder; Association (psychology); Hormone; Case-control study; Genetic association; Endogeny","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[{"model":"gemma","categories":[],"domain":null,"study_design":"meta_analysis","genre":"empirical","about_ca_system":false,"about_ca_topic":false,"confidence":"low","status":"direct model label, unvalidated"},{"model":"gpt","categories":[],"domain":null,"study_design":"systematic_review","genre":"review","about_ca_system":false,"about_ca_topic":false,"confidence":"high","status":"direct model label, unvalidated"}],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.006510145,0.001519116,0.01034893,0.002367637,0.0006556922,0.002176845,0.001609845,0.001884593,0.001859925],"category_scores_gemma":[0.01359629,0.001254582,0.01925889,0.00462542,0.000626195,0.001263225,0.00119214,0.001181022,0.0001953129],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008615367,"about_ca_system_score_gemma":0.001406468,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005940202,"about_ca_topic_score_gemma":0.01370484,"domain_scores_codex":[0.9947973,0.00196845,0.00159846,0.00101906,0.0004028056,0.0002138244],"domain_scores_gemma":[0.9914158,0.005616147,0.001585349,0.0006332012,0.0005851037,0.0001644114],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"meta_analysis","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.003861504,0.00005902024,0.05700903,0.086867,0.8424941,0.0002240531,0.0001438407,0.0003321854,0.0006181796,0.00009296876,0.0004569894,0.007841147],"study_design_scores_gemma":[0.0006588756,0.0002198469,0.03790414,0.003379363,0.9563027,0.000132047,0.00008893698,0.000165113,0.0001179684,0.0001151722,0.0008873923,0.00002846006],"study_design_candidate":"meta_analysis","study_design_consensus":"meta_analysis","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.05238859,0.9447705,0.001106709,0.0001535027,0.000194852,0.0001538793,0.0009762546,0.00002555334,0.0002301741],"genre_scores_gemma":[0.7150317,0.2777095,0.003353856,0.001076739,0.0002229698,0.000412709,0.001762884,0.00003888872,0.0003907108],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.01034893,"threshold_uncertainty_score":0.03442931,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1086914517297116,"score_gpt":0.4246102730758257,"score_spread":0.315918821346114,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}