{"id":"W4416407035","doi":"10.1002/cbic.202500739","title":"Development of a Genetically Encoded and Potent PDE6D Inhibitor","year":2025,"lang":"en","type":"article","venue":"ChemBioChem","topic":"Phosphodiesterase function and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Institute for Research in Immunology and Cancer","funders":"Fonds Wetenschappelijk Onderzoek; Fonds National de la Recherche Luxembourg","keywords":"Prenylation; Small molecule; Chemical biology; Plasma protein binding; HEK 293 cells; Phenotypic screening; Membrane protein; Effector","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006599182,0.00008328551,0.00008732206,0.00002820891,0.00004211975,0.000007310801,0.00004974263,0.00009577258,0.000006594088],"category_scores_gemma":[0.00002700737,0.00007701867,0.00002979748,0.00005828963,0.00006053117,0.000001117317,0.00008993215,0.00002814677,0.000001574012],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009610177,"about_ca_system_score_gemma":0.00009024741,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":6.818447e-7,"about_ca_topic_score_gemma":0.000002992495,"domain_scores_codex":[0.9994776,0.000007285735,0.0001743343,0.0001876791,0.00006037876,0.00009270507],"domain_scores_gemma":[0.999719,0.000003380648,0.00003867383,0.0001388569,0.00006101022,0.00003912722],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004589794,0.00004045651,0.0003696182,0.0000370742,0.00003303112,1.732184e-7,0.00006151163,0.000001648577,0.9874471,0.0001075427,0.0007185342,0.01113743],"study_design_scores_gemma":[0.0003955051,0.00002553648,0.003978965,0.0000242695,0.000008852755,0.000001667887,0.00005241283,0.00002890485,0.9722885,0.00003439362,0.02308253,0.00007841139],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.993566,0.0006910342,0.00285789,0.0001075668,0.0001067662,0.00008601229,0.000001503018,0.000007365864,0.002575824],"genre_scores_gemma":[0.9918767,0.00003994231,0.006118865,0.0001531452,0.00003579174,0.00001109996,0.00004111848,0.000005303329,0.001718096],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02236399,"threshold_uncertainty_score":0.314073,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00585385825910372,"score_gpt":0.2275505234201055,"score_spread":0.2216966651610018,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}