{"id":"W4416407035","doi":"10.1002/cbic.202500739","title":"Development of a Genetically Encoded and Potent PDE6D Inhibitor","year":2025,"lang":"en","type":"article","venue":"ChemBioChem","topic":"Phosphodiesterase function and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Institute for Research in Immunology and Cancer","funders":"Fonds Wetenschappelijk Onderzoek; Fonds National de la Recherche Luxembourg","keywords":"Prenylation; Small molecule; Chemical biology; Plasma protein binding; HEK 293 cells; Phenotypic screening; Membrane protein; Effector","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000200035,0.0003900729,0.0003408881,0.0002430792,0.0001466016,0.0002779623,0.0003943244,0.0004482298,0.001129876],"category_scores_gemma":[0.0001331672,0.0001872042,0.0003260268,0.000181078,0.0001745277,0.0002410293,0.0002711903,0.0008390269,0.0006620109],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003589516,"about_ca_system_score_gemma":0.0002765827,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004344077,"about_ca_topic_score_gemma":0.0006255771,"domain_scores_codex":[0.9998721,0.00001114064,0.00001682553,0.00003061136,0.00004631178,0.00002292814],"domain_scores_gemma":[0.9999387,0.000007466255,0.00001433243,0.000008913144,0.0000108583,0.00001974355],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005763054,0.00005064692,0.00004600026,0.00006376309,0.000007827531,0.00005009278,0.000009128891,0.0002083756,0.9956565,0.000235698,0.00009773115,0.003516504],"study_design_scores_gemma":[0.00002559065,0.0003227013,0.0002869521,0.00000470344,0.0000164388,0.0001881327,0.000004494398,0.0007086116,0.9915024,0.00002531377,0.006909307,0.000005345466],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9015642,0.01041552,0.06950954,0.0006373612,0.0002313008,0.000661828,0.002653646,0.0007396467,0.01358688],"genre_scores_gemma":[0.9387872,0.005949456,0.04268194,0.0002071064,0.00003121875,0.0002444057,0.002899568,0.00007795698,0.00912119],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001129876,"threshold_uncertainty_score":0.003779769,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00585385825910372,"score_gpt":0.2275505234201055,"score_spread":0.2216966651610018,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}