{"id":"W4416407690","doi":"10.3390/biomedicines13112825","title":"Mass Spectrometry for Lysine Methylation: Principles, Progress, and Prospects","year":2025,"lang":"en","type":"article","venue":"Biomedicines","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Carleton University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Lysine; Methylation; Mass spectrometry; Fragmentation (computing); Histone; Tandem mass spectrometry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.007932233,0.002068566,0.001548268,0.00271512,0.0007756104,0.002280479,0.001848654,0.002435436,0.002061755],"category_scores_gemma":[0.003928656,0.0007698759,0.000852546,0.00205104,0.002255075,0.004558811,0.002491065,0.004243175,0.002712043],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001236265,"about_ca_system_score_gemma":0.001536074,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007482379,"about_ca_topic_score_gemma":0.001009934,"domain_scores_codex":[0.9972588,0.0008218029,0.0001057326,0.0005606186,0.001100378,0.0001527645],"domain_scores_gemma":[0.9980615,0.0008177517,0.0001829099,0.0002332385,0.0005686887,0.000135985],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0004099323,0.0002608135,0.002678772,0.007462454,0.000522887,0.0006670581,0.0005874147,0.002495712,0.2675012,0.07134094,0.03150227,0.6145706],"study_design_scores_gemma":[0.0001047517,0.0008440476,0.003505845,0.002005601,0.0002388496,0.003454261,0.0003651488,0.01255989,0.2306462,0.07876997,0.6671287,0.0003768671],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.008515629,0.7020432,0.2618828,0.01159043,0.001963414,0.0002175503,0.0005477995,0.001333672,0.01190554],"genre_scores_gemma":[0.06881949,0.6235518,0.2886491,0.00677785,0.002972947,0.0004057285,0.0008800473,0.0005103682,0.007432722],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.007932233,"threshold_uncertainty_score":0.04195017,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01388878998308929,"score_gpt":0.2929509322795797,"score_spread":0.2790621422964904,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}