{"id":"W4416407690","doi":"10.3390/biomedicines13112825","title":"Mass Spectrometry for Lysine Methylation: Principles, Progress, and Prospects","year":2025,"lang":"en","type":"article","venue":"Biomedicines","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Carleton University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Lysine; Methylation; Mass spectrometry; Fragmentation (computing); Histone; Tandem mass spectrometry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002135522,0.0001094527,0.0001289407,0.0001142729,0.00007269576,0.00001991928,0.00006952976,0.00009723757,0.000004062817],"category_scores_gemma":[0.0001218839,0.00009118379,0.0000344715,0.0002215837,0.0001161625,0.000002308317,0.00003992202,0.00002776136,5.609014e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009518074,"about_ca_system_score_gemma":0.00004880929,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002392131,"about_ca_topic_score_gemma":0.000004581009,"domain_scores_codex":[0.999307,0.00001542381,0.0001746417,0.0002747579,0.00008126118,0.0001469523],"domain_scores_gemma":[0.9995852,0.00001856655,0.00006146438,0.0001872221,0.000103246,0.00004431388],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006308153,0.00003534638,0.02896965,0.0001248167,0.00007186587,6.551952e-7,0.00001372655,0.000002161123,0.9562613,0.003081796,0.0007068596,0.01066878],"study_design_scores_gemma":[0.001311825,0.0005184317,0.04106251,0.00005014197,0.00007260135,0.000001387246,0.00003543981,0.0002749955,0.682517,0.00537475,0.268586,0.0001949047],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8012155,0.0820588,0.1049142,0.005019954,0.0008362365,0.001457085,0.00003704625,0.00005560449,0.004405566],"genre_scores_gemma":[0.9742728,0.0007731087,0.02150198,0.0001105899,0.0005291717,0.00007751578,0.0001961166,0.000014126,0.002524511],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2737443,"threshold_uncertainty_score":0.3718367,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01388878998308929,"score_gpt":0.2929509322795797,"score_spread":0.2790621422964904,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}